1257227-17-0

Basic information

• Product Name: 3-chloro-4,5-dimethoxyphenyl(tosyl)methyl isocyanide
• Synonyms: 3-chloro-4,5-dimethoxyphenyl(tosyl)methyl isocyanide
• CAS NO: 1257227-17-0
• Molecular Weight: 365.837
• Mol File: 1257227-17-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-chloro-4,5-dimethoxyphenyl(tosyl)methyl isocyanide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-4,5-dimethoxyphenyl(tosyl)methyl isocyanide(1257227-17-0)
• EPA Substance Registry System: 3-chloro-4,5-dimethoxyphenyl(tosyl)methyl isocyanide(1257227-17-0)

Safety Data

• Hazardous Substances Data: 1257227-17-0(Hazardous Substances Data)

Upstream product

• 1245716-01-1 N-[(toluene-4-sulfonyl)-(3-chloro-4,5-dimethoxyphenyl)methyl]formamide 
• 18268-68-3 5-chloroveratraldehyde 
• 104-15-4 toluene-4-sulfonic acid 

Downstream Products

• 1257227-19-2 4-(3'-chloro-4',5'-dimethoxyphenyl)-5-(4''-methoxy-3''-tetrahydropyranyloxyphenyl)-oxazole 
• 1627130-72-6 4-(3-chloro-4,5-dimethoxyphenyl)-5-(4-methoxyphenyl)-1-methylimidazole 
• 1627130-75-9 4-(3-chloro-4,5-dimethoxyphenyl)-5-(4-methoxyphenyl)-1-ethylimidazole 
• 1345962-03-9 3-chloro-1-methyl-5-[1-methyl-4-(3-chloro-4,5-dimethoxyphenyl)-imidazol-5-yl]indole 
• 1245766-65-7 1-methyl-5-(3''-amino-4''-methoxyphenyl)-4-(3'-chloro-4',5'-dimethoxyphenyl)imidazole 
• 1345962-13-1 1-methyl-5-(3-amino-4-ethoxyphenyl)-4-(3-chloro-4,5-dimethoxyphenyl)imidazole 
• 1345962-02-8 1-methyl-4-(3-chloro-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole hydrochloride 
• 1345962-15-3 1-methyl-4-(3-chloro-4,5-dimethoxyphenyl)-5-(3-fluoro-4-ethoxyphenyl)imidazole 
• 1345962-00-6 1-methyl-4-(3-chloro-4,5-dimethoxyphenyl)-5-(4-ethoxy-3-nitrophenyl)imidazole 
• 1245716-07-7 1-methyl-4-(3'-chloro-4',5'-dimethoxyphenyl)-5-(4''-methoxy-3''-nitrophenyl)imidazole 

Relevant articles and documents

COMBRETASTATIN ANALOGS FOR USE IN THE TREATMENT OF CANCER

The present invention relates to specific analogs of combretastatin, in particular the compounds of formula (I) as described and defined herein, and pharmaceutical compositions comprising the compounds, as well as their medical use, in particular in the treatment or prevention of cancer, including multidrug-resistant cancer.

4-(3-Halo/amino-4,5-dimethoxyphenyl)-5-aryloxazoles and-N-methylimidazoles That Are cytotoxic against combretastatin a resistant tumor cells and vascular disrupting in a cisplatin resistant germ cell tumor model

New combretastatin A analogues featuring oxazole or N-methylimidazole bridged Z-alkenes and halo-or amino-substituted A-rings were tested against various cancer cell lines and in testicular germ cell tumor xenografts in mice. Imidazoles with 3-halo-4,5-dimethoxy substituted A-rings and 3-amino-4-methoxy substituted B-rings (7b and 8b) were efficacious at nanomolar concentrations against cells of combretastatin A refractory HT-29 colon carcinoma, multidrug-resistant MCF-7/Topo breast carcinoma, and cisplatin-resistant 1411HP testicular germ cell tumor. They induced apoptosis and inhibited tubulin polymerization. While well tolerated by mice at high doses, these imidazoles initiated extensive intratumoral hemorrhage and regressions of highly vascularized 1411HP xenografts.