1345962-03-9Relevant academic research and scientific papers
Combretastatin A-4 derived 5-(1-methyl-4-phenyl-imidazol-5-yl)indoles with superior cytotoxic and anti-vascular effects on chemoresistant cancer cells and tumors
Mahal, Katharina,Biersack, Bernhard,Schruefer, Sebastian,Resch, Marcus,Ficner, Ralf,Schobert, Rainer,Mueller, Thomas
, p. 9 - 20 (2016/05/10)
5-(1-Methyl-4-phenyl-imidazol-5-yl)indoles 5 were prepared and tested as analogs of the natural vascular-disrupting agent combretastatin A-4 (CA-4). The 3-bromo-4,5-dimethoxyphenyl derivative 5c was far more active than CA-4 with low nanomolar IC50/
COMBRETASTATIN ANALOGS FOR USE IN THE TREATMENT OF CANCER
-
Page/Page column 36, (2011/11/30)
The present invention relates to specific analogs of combretastatin, in particular the compounds of formula (I) as described and defined herein, and pharmaceutical compositions comprising the compounds, as well as their medical use, in particular in the treatment or prevention of cancer, including multidrug-resistant cancer.
