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Upstream product

• 100-19-6 (4-nitrophenyl)ethanone 
• 143704-82-9 methyl 4-bromo-3-(4-nitrophenyl)-2-butenoate 
• 121-45-9 phosphorous acid trimethyl ester 
• 144465-18-9 methyl (E)-3-(4-nitrophenyl)-3-methylacrylate 

Relevant academic research and scientific papers

Enantioselective Rh-catalyzed hydrogenation of 3-aryl-4-phosphonobutenoates with a P-stereogenic BoPhoz-type ligand

A series of chiral 3-aryl-4-phosphonobutyric acid esters were synthesized in high enantioselectivities (93-98% ee) via the Rh-catalyzed asymmetric hydrogenation of the corresponding 3-aryl-4-phosphonobutenoates using a P-stereogenic BoPhoz-type phosphine-aminophosphine ligand. The methodology has been successfully applied to the asymmetric synthesis of a potential GABA B antagonist, (R)-phaclofen, in high enantioselectivity.