1257246-75-5

Upstream product

• 99-91-2 para-chloroacetophenone 
• 1257246-62-0 methyl 3-(4-chlorophenyl)-4-(dimethoxyphosphoryl)but-2-enoate 
• 1257246-51-7 C₁₁H₁₀BrClO₂ 

Downstream Products

• 160866-55-7 (R)-phaclofen 

Relevant academic research and scientific papers

An enantioselective synthesis of 3-aryl-4-phosphonobutyric acid esters via Cu-catalyzed asymmetric conjugate reduction

The asymmetric conjugate reduction of 3-aryl-4-phosphonobutenoates has been demonstrated which provides an enantioselective synthesis of optically active 3-aryl-4-phosphonobutyric acid esters. A wide range of 3-aryl-4- phosphonobutenoate derivates are red

Enantioselective Rh-catalyzed hydrogenation of 3-aryl-4-phosphonobutenoates with a P-stereogenic BoPhoz-type ligand

A series of chiral 3-aryl-4-phosphonobutyric acid esters were synthesized in high enantioselectivities (93-98% ee) via the Rh-catalyzed asymmetric hydrogenation of the corresponding 3-aryl-4-phosphonobutenoates using a P-stereogenic BoPhoz-type phosphine-aminophosphine ligand. The methodology has been successfully applied to the asymmetric synthesis of a potential GABA B antagonist, (R)-phaclofen, in high enantioselectivity.