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Upstream product

• 93404-35-4 E-methyl β-methyl-p-chlorocinnamate 
• 99-91-2 para-chloroacetophenone 
• 1257246-75-5 methyl (3S)-3-(4-chlorophenyl)-4-(dimethoxyphosphoryl)butanoate 
• 1257246-62-0 methyl 3-(4-chlorophenyl)-4-(dimethoxyphosphoryl)but-2-enoate 
• 1257246-51-7 C₁₁H₁₀BrClO₂ 

Relevant academic research and scientific papers

Enantioselective Rh-catalyzed hydrogenation of 3-aryl-4-phosphonobutenoates with a P-stereogenic BoPhoz-type ligand

A series of chiral 3-aryl-4-phosphonobutyric acid esters were synthesized in high enantioselectivities (93-98% ee) via the Rh-catalyzed asymmetric hydrogenation of the corresponding 3-aryl-4-phosphonobutenoates using a P-stereogenic BoPhoz-type phosphine-aminophosphine ligand. The methodology has been successfully applied to the asymmetric synthesis of a potential GABA B antagonist, (R)-phaclofen, in high enantioselectivity.