1257268-75-9Relevant academic research and scientific papers
Selectfluor-promoted fluorination of piperidinyl olefins
Chang, Meng-Yang,Lee, Nien-Chia,Lee, Ming-Fang,Huang, Yu-Ping,Lin, Chung-Han
experimental part, p. 5900 - 5903 (2010/11/21)
A simple and straightforward synthesis of 1-substituted-4-aryl-5-fluoro-1, 2,3,6-tetrahydropyridine (3) or 1-substituted 4-diarylmethanoyl-4- fluoropiperidine (6) by the treatment of piperidinyl exo- or endo-olefin with 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate (Selectfluor) is reported. Two transformations from endo-olefin 1 to allylic fluoride 3 and from exo-olefin 2 to fluorohydrin 6 proceed via allylic fluorination and fluorohydroxylation in moderate yields. It presents two novel reactions promoted by Selectfluor and broadens the scope of application.
