30125-24-7

Upstream product

• 64-18-6 formic acid 
• 4404-61-9 cyclohexyldiphenylmethanol 
• 506-96-7 Acetyl bromide 
• 408331-13-5 2,2-diphenyl-cycloheptanol 
• 144-62-7 oxalic acid 
• 64-19-7 acetic acid 
• 119-61-9 benzophenone 
• 60-29-7 diethyl ether 
• 931-50-0 cyclohexylmagnesium bromide 
• 108-94-1 cyclohexanone 
• 2051-90-3 Dichlorodiphenylmethane 
• 35121-96-1 3,3-diphenyl-1-oxa-4-thia-spiro[4.5]decan-2-one 
• 50421-26-6 1-(tribromomethyl)cyclohexanol 
• 60014-85-9 (1,1-dibromomethylene)cyclohexane 

Downstream Products

• 63865-83-8 2,2-diphenyl-1-oxa-spiro[2.5]octane 
• 50585-08-5 (cyclohexylmethylene)dibenzene 
• 102171-60-8 2,2-diphenyl-1-oxa-spiro[2.5]octan-4-ol 
• 103509-84-8 2,2'-dibenzhydrylidene-bicyclohexyl 
• 120857-31-0 4-(2-benzhydrylidene-cyclohexyl)-2,2-diphenyl-1-oxa-spiro[2.5]octane 
• 70422-35-4 1,1-Dichlor-2,2-diphenylspiro<2.5>octan 
• 83605-32-7 1,1′-(1-cyclohexen-1-ylmethylene)bisbenzene 
• 124-04-9 Adipic acid 
• 119-61-9 benzophenone 
• 1028938-89-7 1-(4-(cyclohexylidene(phenyl)methyl)phenyl)ethanone 
• 1257268-75-9 C₁₉H₂₁FO 
• 56537-38-3 1-(1-Cyclohexenyl)-1,1-diphenylethan 

Relevant academic research and scientific papers

Synthesis of Allylboronates via Zweifel-type Deprotonative Olefination

A method for the synthesis of allylboronates via Zweifel-type deprotonative olefination was demonstrated. Tetrasubstituted vinylboronates were used as the substrates. NCS (N-chlorosuccinimide) was used as a bifunctional additive, electrophile and base. This method exhibited a different elimination strategy in Zweifel type transformation to afford allylboronates. The homo-alcohols and alkenes were stereoselective synthesized from the obtained allylboronates, demonstrating the synthetic value of this methodology. (Figure presented.).

P2Y12 receptor antagonist for nitrile diphenyl thioacetic acid structure and application of P2Y12 receptor antagonist

The invention relates to the field of medicines associated with cardiovascular diseases, in particular to a P2Y12 receptor antagonist containing a nitrile diphenyl thioacetic acid structure, a preparation method of the P2Y12 receptor antagonist as well as application of the P2Y12 receptor antagonist in preparing a medicine for treating the cardiovascular diseases, in particular to thromboembolic disease. (The formula is shown in the description).

P2Y12 receptor antagonists diphenyl thioacetic acid, preparation method and use thereof (by machine translation)

The present invention relates to cardiovascular diseases associated with the medicine field. Specifically, the invention relates to a diphenyl thioacetic acid structure of the P2Y12 receptor antagonists, its preparation method and thereof in the preparation of the treatment of cardiovascular diseases in particular thromboembolic disease in the application. Wherein R1 Is selected from H, C1 - C6 Alkyl; R2 Is selected from H, C1 - C6 Alkyl, C3 - C8 A cycloalkyl. (by machine translation)

Sp3-sp2 C-C bond formation via Bronsted acid trifluoromethanesulfonic acid-catalyzed direct coupling reaction of alcohols and alkenes

A novel and efficient trifluoromethanesulfonic acid-catalyzed sp 3-sp2 Ci￡C bond formation reaction through the direct coupling of alcohols with alkenes has been realized under mild conditions. The present protocol provides an attractive approach to a diverse range of polysubstituted olefins in good to excellent yields with high stereo- and regioselectivities. Copyright

Weakening C-O bonds: Ti(III), a new reagent for alcohol deoxygenation and carbonyl coupling olefination

Investigations detailed herein, including density functional theory (DFT) calculations, demonstrate that the formation of either alkoxy- or hydroxy-Ti(III) complexes considerably decreases the energy of activation for C-O bond homolysis. As a consequence of this observation, we described two new synthetic applications of Nugent's reagent in organic chemistry. The first of these applications is an one-step methodology for deoxygenation-reduction of alcohols, including benzylic and allylic alcohols and 1,2-dihydroxy compounds. Additionally, we have also proved that Ti(III) is capable of mediating carbonyl coupling-olefination. In this sense, and despite the fact that for over 35 years it has been widely accepted that either Ti(II) or Ti(0) was the active species in the reductive process of the McMurry reaction, the mechanistic evidence presented proves the involvement of Ti(III) pinacolates in the deoxygenation step of the herein described Nugent's reagent-mediated McMurry olefination. This observation sheds some light on probably one of the mechanistically more complex transformations in organic chemistry. Finally, we have also proved that both of these processes can be performed catalytically in Cp 2TiCl2 by using trimethylsilyl chloride (TMSCl) as the final oxygen trap.

Insights into the general and efficient cross McMurry reactions between ketones

The selective cross McMurry couplings of diaryl or aryl ketones with various substituted ketones were achieved in 53-94% isolated yields. It is believed that the strong affinity of the substituents to the low-valent titanium surface plays an important role in regards to moderating selectivity. Through the introduction of such substituents followed by their removal post McMurry coupling, structurally similar ketones can be effectively cross-coupled.

Geminal dimetalation of alkylidene-type carbenoids with silylboranes and diborons

A novel and efficient method for gem-dimetalation of carbenoids has been demonstrated. Treatment of alkylidene-type lithium carbenoids with such an interelement compound as silylborane or diboron to generate the corresponding borate complex, followed by warming to room temperature, induced migration of the silyl or boryl group from a negatively charged boron atom to the carbenoid carbon to afford 1-boryl-1-silyl-1-alkenes or 1,1-diboryl-1-alkenes in good yields. Carbon-carbon bond forming transformations of the gem-dimetalated compounds mediated by boron or silicon is also described.

Geminal difunctionalization of alkenylidene-type carbenoids by using interelement compounds

A 1,2 migration of a boryl or silyl group with inversion of configuration occurs in the reaction of alkylidene-type lithium carbenoids with diboron or silylborane derivatives to give the corresponding 1,1-diboryl-or 1-boryl-1-silylalkenes in good yields (

Synthesis of trisubstituted and tetrasubstituted alkenes via a manganate-induced migration-elimination process

Preparation of alkenes via a manganate-induced alkylation-elimination sequence was investigated. The reaction of 2-alkoxy-1,1-dibromoalkanes with trialkylmanganates afforded disubstituted or trisubstituted alkenes. Treatment of 2-alkoxy-1,1,1-tribromoalkanes with trialkylmanganates provided trisubstituted or tetrasubstituted alkenes through bromine-metal exchange, transfer of two alkyl groups from manganese to carbon, and successive elimination of metal and the β-alkoxy moieties.

Cyproheptadine analogues: Synthesis, antiserotoninergic activity, and structure-activity relationships

A series of cyproheptadine related compounds was synthesized and tested pharmacologically. In comparison with cyproheptadine, these compounds do not have a central ring and some contain groups other than N-methyl. Synthesis was carried out with low-valent