125729-46-6 Usage
General Description
1’-hydroxybenzbromarone is a metabolite of benzbromarone, an uric acid-lowering drug used to treat gout. This chemical has been shown to have potent uricosuric effects, meaning it increases the excretion of uric acid from the body. It achieves this by inhibiting the reabsorption of uric acid in the kidneys, ultimately leading to a decrease in uric acid levels in the bloodstream. This property makes 1’-hydroxybenzbromarone a promising candidate for the treatment of conditions related to elevated uric acid levels, such as gout and hyperuricemia. Additionally, research has suggested that this metabolite may also have anti-inflammatory and antioxidant properties, further expanding its potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 125729-46-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,5,7,2 and 9 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 125729-46:
(8*1)+(7*2)+(6*5)+(5*7)+(4*2)+(3*9)+(2*4)+(1*6)=136
136 % 10 = 6
So 125729-46-6 is a valid CAS Registry Number.
125729-46-6Relevant articles and documents
Charge and substituent effects on affinity and metabolism of benzbromarone-based CYP2C19 inhibitors
Locuson II, Charles W.,Suzuki, Hisashi,Rettie, Allan E.,Jones, Jeffrey P.
, p. 6768 - 6776 (2004)
Human cytochrome P450 (CYP) 2C19 is one of the most important CYP2C family members responsible for metabolizing commonly prescribed drugs. This research describes synthetic modifications to benzbromarone (Bzbr) to create the most potent CYP2C19 inhibitor
