1257293-78-9

Basic information

• Product Name: 2-Azetidin-3-yl-propan-2-ol
• Synonyms: 2-Azetidin-3-yl-propan-2-ol;3-(2-Hydroxyprop-2-yl)azetidine
• CAS NO: 1257293-78-9
• Molecular Formula: C6H13NO
• Molecular Weight: 115.17352
• Mol File: 1257293-78-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Azetidin-3-yl-propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Azetidin-3-yl-propan-2-ol(1257293-78-9)
• EPA Substance Registry System: 2-Azetidin-3-yl-propan-2-ol(1257293-78-9)

Safety Data

• Hazardous Substances Data: 1257293-78-9(Hazardous Substances Data)

Usage

General Description

2-Azetidin-3-yl-propan-2-ol is a chemical compound with the molecular formula C7H13NO. It is a tertiary alcohol with a cyclic structure containing a four-membered nitrogen-containing ring. 2-Azetidin-3-yl-propan-2-ol is used as a building block in organic synthesis, particularly in the pharmaceutical industry to create new drugs and medications. It has been studied for its potential as a chiral auxiliary in asymmetric synthesis, and its unique structure and properties make it a valuable tool for creating complex organic molecules. Additionally, 2-Azetidin-3-yl-propan-2-ol has potential applications in materials science and as a reagent in chemical transformations.

Upstream product

• 1257293-79-0 tert-butyl 3-(2-hydroxypropan-2-yl)azetidine-1-carboxylate 
• 610791-05-4 azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester 

Relevant articles and documents

Synthesis and biological evaluation of 4-(pyridine-4-oxy)-3-(tetrahydro-2H-pyran-4-yl)-pyrazole derivatives as novel, potent of ALK5 receptor inhibitors

The transforming growth factor type β receptor I (TGF-β R1, also known as activin-like kinase 5 or ALK5) plays a significant role in the pathogenesis of multiple diseases such as malignant tumors and tissue fibrosis. Specific inhibition of ALK5 provides a novel method for controlling the development of cancers and fibrotic diseases. Herein, a novel series of 4-(pyridine-4-oxy)-3-(tetrahydro-2H-pyran-4-yl)-pyrazole derivatives was synthesized and identified as ALK5 inhibitors. Among them, compound 8h inhibited ALK5 autophosphorylation and NIH3T3 cell activity with IC50 values of 25 nM and 74.6 nM, respectively. Compound 8h also showed favorable pharmacokinetic profile and ameliorated hERG inhibition. More importantly, 30 mg/kg oral administration of 8h could significantly induce tumour growth inhibition in CT26 xenograft model without obvious toxicity.