1257293-79-0

Basic information

• Product Name: 1-Boc-3-(1-hydroxy-1-Methylethyl)-azetidine
• Synonyms: 1-Boc-3-(1-hydroxy-1-Methylethyl)-azetidine;tert-Butyl 3-(2-hydroxypropan-2-yl)azetidine-1-carboxylate;tert-butyl 3-(1-Hydroxy-1-methyl-ethyl)azetidine-1-carboxylate;1-Azetidinecarboxylic acid, 3-(1-hydroxy-1-methylethyl)-, 1,1-dimethylethyl ester
• CAS NO: 1257293-79-0
• Molecular Formula: C11H21NO3
• Molecular Weight: 215.28934
• Mol File: 1257293-79-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Boc-3-(1-hydroxy-1-Methylethyl)-azetidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-3-(1-hydroxy-1-Methylethyl)-azetidine(1257293-79-0)
• EPA Substance Registry System: 1-Boc-3-(1-hydroxy-1-Methylethyl)-azetidine(1257293-79-0)

Safety Data

• Hazardous Substances Data: 1257293-79-0(Hazardous Substances Data)

Usage

General Description

1-Boc-3-(1-hydroxy-1-Methylethyl)-azetidine, also known as tert-butyl 3-(1-hydroxy-1-methylethyl)azetidine-1-carboxylate, is a chemical compound with the molecular formula C11H21NO3. It is commonly used in organic synthesis as a building block for the creation of various pharmaceuticals, agrochemicals, and materials. The compound is a white solid at room temperature and is stable under normal conditions. Its unique structure and properties make it a valuable tool for the development of new chemical compounds and materials in the field of organic chemistry.

Upstream product

• 610791-05-4 azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 1357923-33-1 2-(azetidin-3-yl)propan-2-ol hydrochloride 

Relevant articles and documents

Synthesis and biological evaluation of 4-(pyridine-4-oxy)-3-(tetrahydro-2H-pyran-4-yl)-pyrazole derivatives as novel, potent of ALK5 receptor inhibitors

The transforming growth factor type β receptor I (TGF-β R1, also known as activin-like kinase 5 or ALK5) plays a significant role in the pathogenesis of multiple diseases such as malignant tumors and tissue fibrosis. Specific inhibition of ALK5 provides a novel method for controlling the development of cancers and fibrotic diseases. Herein, a novel series of 4-(pyridine-4-oxy)-3-(tetrahydro-2H-pyran-4-yl)-pyrazole derivatives was synthesized and identified as ALK5 inhibitors. Among them, compound 8h inhibited ALK5 autophosphorylation and NIH3T3 cell activity with IC50 values of 25 nM and 74.6 nM, respectively. Compound 8h also showed favorable pharmacokinetic profile and ameliorated hERG inhibition. More importantly, 30 mg/kg oral administration of 8h could significantly induce tumour growth inhibition in CT26 xenograft model without obvious toxicity.

BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE

Compounds of Formula (I) are useful inhibitors of anaplastic lymphoma kinase. Compounds of Formula (I) have the following structure: where the definitions of the variables are provided herein.