125732-40-3

Basic information

• Product Name: ethyl 5-Methyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate
• Synonyms: ethyl 5-Methyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate;5-Hydroxy-3-methyl-1H-pyrazole-4-carboxylic acid ethyl ester
• CAS NO: 125732-40-3
• Molecular Formula: C₇H₁₀N₂O₃
• Molecular Weight: 170.1659
• EINECS: -0
• Mol File: 125732-40-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 5-Methyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-Methyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate(125732-40-3)
• EPA Substance Registry System: ethyl 5-Methyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate(125732-40-3)

Safety Data

• Hazardous Substances Data: 125732-40-3(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 19, p. 2087, 1989 DOI: 10.1080/00397918908052602

Upstream product

• 105-53-3 diethyl malonate 
• 102626-05-1 ethyl 3-amino-2-phenylaminocarbonyl-2-butenoate 
• 137786-67-5 ethyl 3-amino-2-ethoxycarbonyl-2-butenoate 
• 31575-84-5 (1-hydroxyethylidene)malonic acid diethyl ester 
• 5456-14-4 3,5-diethoxy-carbonyl-2,6-dimethyl-4H-pyran-4-one 
• 570-08-1 diethyl acetylmalonate 

Downstream Products

• 1288961-01-2 3-(2,4-dichlorophenyl)-6-methylpyrazolo[5,1-b][1,3]oxazole-7-carboxylic acid 
• 1288960-98-4 ethyl 3-(2,4-dichlorophenyl)-6-methylpyrazolo[5,1-b][1,3]oxazole-7-carboxylate 
• 1207259-65-1 3-[2-(2,4-dimethyl-phenyl)-1-methyl-2-oxo-ethoxy]-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester 

Relevant articles and documents

1,5,7-TRISUBSTITUTED ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF IN MEDICINES

The present disclosure relates to 1,5,7-trisubstituted isoquinoline derivatives, their preparation and pharmaceutical use. In particular, the present disclosure discloses a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, and a preparation method and use thereof. The definitions of the groups in the formula can be found in the specification and claims.

Organic compounds

There are described pyrazolo[5.1-b]oxazole derivatives useful as corticotropin releasing factor (CRF1) receptor antagonists.

Synthesis of 3-substituted and 3,4-disubstituted pyrazolin-5-ones

The synthesis of 3-substituted and 3,4-disubstituted pyrazolin-5-ones from acylated ethyl acetoacetates and diethyl malonates is described. The reaction of acylated ethyl acetoacetates and diethyl acetylmalonate with hydrazine (98%) gave 3-substituted pyrazolin-5-ones and malonyldihydrazide, respectively, following a deacetylation-condensation sequence. The reaction of ethyl 2-acetyl-3-hydroxy-2-butenoate and diethyl 2-(1-hydroxyethylidene)malonate with hydrazine monohydrochloride yielded ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate and 4-ethoxycarbonyl-3-methylpyrazolin-5-one, respectively, following a dehydration-cyclocondensation sequence, in high yields.