1257328-40-7

Basic information

• Product Name: C₂₁H₂₁ClN₄O₂S
• CAS NO: 1257328-40-7
• Molecular Weight: 428.942
• Mol File: 1257328-40-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₁ClN₄O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₁ClN₄O₂S(1257328-40-7)
• EPA Substance Registry System: C₂₁H₂₁ClN₄O₂S(1257328-40-7)

Safety Data

• Hazardous Substances Data: 1257328-40-7(Hazardous Substances Data)

Upstream product

• 778574-06-4 6-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidine 
• 5183-78-8 methyl(phenylsulfonyl)amide 

Downstream Products

• 1208123-71-0 C₂₉H₃₁N₅O₂S 

Relevant articles and documents

5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidines as novel class of potent and highly selective CaMKII inhibitors

A novel series of 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidines containing substituted phenyl sulfonamide are synthesized and evaluated for their inhibitory activity against CaMKII. Substituents on the phenyl group had significant impact on CaMKII inhibition, in particular, the inhibitory activity of 8p was 25-fold higher than that of KN-93, a known CaMKII inhibitor. Michaelis-Menten analysis of a representative compound suggested that the synthesized pyrimidines are calmodulin non-competitive inhibitors. Finally, 8p exhibited more than 100-fold higher selectivity for CaMKII over five types of off-target kinases.