1257330-58-7Relevant articles and documents
New non-hydroxamic ADAMTS-5 inhibitors based on the 1,2,4-triazole-3-thiol scaffold
Maingot, Lucie,Leroux, Florence,Landry, Valérie,Dumont, Julie,Nagase, Hideaki,Villoutreix, Bruno,Sperandio, Olivier,Deprez-Poulain, Rebecca,Deprez, Benoit
supporting information; experimental part, p. 6213 - 6216 (2010/11/19)
In this Letter we describe the design, synthesis, screening, and optimization of a new family of ADAMTS-5 inhibitors. These inhibitors display an original 1,2,4-triazole-3-thiol scaffold as a putative zinc binding-group. In vitro results are rationalized