1924-77-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Phenylbenzylamine hydrochloride is used as a reactant in the synthesis of various pharmaceuticals for its ability to contribute to the formation of active ingredients in medications.
Used in Dye and Pigment Production:
2-Phenylbenzylamine hydrochloride is utilized as a reactant in the production of dyes and pigments, where its chemical properties aid in creating a range of colorants for different applications.

InChI:InChI=1/C13H13N/c14-10-12-8-4-5-9-13(12)11-6-2-1-3-7-11/h1-9H,10,14H2

Upstream product

• 24973-49-7 biphenyl-2-carbonitrile 
• 1924-78-3 N-2-Biphenylylmethyl-2-biphenylylmethylen-amin 
• 123-51-3 i-Amyl alcohol 
• 1203-68-5 2-Phenylbenzaldehyde 
• 2042-37-7 o-cyanobromobenzene 
• 3959-05-5 2-bromobenzylamine 
• 98-80-6 phenylboronic acid 
• 4387-36-4 2-iodobenzonitrile 
• 187884-94-2 N-(2-phenyl-phenylmethyl)-phthalimide 

Downstream Products

• 385836-47-5 3-{4-[3-Biphenyl-2-ylmethyl-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}-2(R)-hydroxypropionic acid 
• 257939-97-2 2-ethyl-1,5,6,7-tetrahydro-1-(2-phenyl-phenylmethyl)-4H-indol-4-one 
• 1257330-57-6 4-(4-phenylbenzyl)-5-(2-(5-methyl[1,2,4]oxadiazol-3-yl)phenyl)-2,4-dihydro[1,2,4]triazole-3-thiol potassium salt 
• 1257330-58-7 5-(4-phenylbenzyl)-4-(4-phenylbenzyl)-2,4-dihydro[1,2,4]triazole-3-thiol potassium salt 
• 1257330-47-4 5-(4-chlorobenzyloxymethyl)-4-(2-phenylbenzyl)-2,4-dihydro[1,2,4]triazole-3-thiol potassium salt 
• 1610415-58-1 1-([1,1'-biphenyl]-2-ylmethyl)-3-(1'.4-dimethyl-1-phenyl-1H,1'H-[3,4'-bipyrazol]-5-yl)urea 
• 84-15-1 o-terphenyl 
• 13737-31-0 N-methyl-2-aminomethylbiphenyl 
• 486-25-9 9-fluorenone 
• 1203-68-5 2-Phenylbenzaldehyde 

Relevant academic research and scientific papers

Synthesis of highly substituted fluorenones via metal-free TBHP-promoted oxidative cyclization of 2-(aminomethyl)biphenyls. Application to the total synthesis of nobilone

Highly substituted fluorenones are readily prepared in mostly fair to good yields via metal- and additive-free TBHP-promoted cross-dehydrogenative coupling (CDC) of readily accessible N-methyl-2-(aminomethyl)biphenyls and 2-(aminomethyl)biphenyls. This methodology is compatible with numerous functional groups (methoxy, cyano, nitro, chloro, and SEM and TBS-protective groups for phenols) and was further utilized in the first total synthesis of the natural product nobilone.

Preparation of phenanthridines from N-(o-arylbenzyl)trifluoromethanesulfonamides with 1,3-diiodo-5,5-dimethylhydantoin

Treatment of N-(o-arylbenzyl)trifluoromethanesulfonamides with 1,3-diiodo-5,5-dimethylhydantoin in 1,2-dichloroethane under irradiation with a tungsten lamp, followed by the reaction with tBuOK gave the corresponding 6-arylphenanthridines and 6-unsubstituted phenanthridines in good to moderate yields, respectively. The reaction proceeds through an oxidative cyclization onto the aromatic ring by sulfonamidyl radicals formed from the N-iodosulfonamides. The present reaction is a one-pot method for the preparation of both 6-arylphenanthridines and 6-unsubstituted phenanthridines from N-(o-arylbenzyl)trifluoromethanesulfonamides under transition-metal-free conditions.

Synthesis of phenanthridines through iodine-supported intramolecular C-H amination and oxidation under visible light

Herein, we report a metal-free and step-economic synthesis of phenanthridines from 2-biarylmethanamines under mild conditions. The reaction involves iodine-supported intramolecular C-H amination and oxidation of 5,6-dihydrophenanthridine under air and benign visible light. The mechanism study reveals that visible light plays a key role in both these steps.

Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression

5-HT7 receptor (5-HT7R) is a promising target for the treatment of depression and neuropathic pain. 5-HT7R antagonists exhibited antidepressant effects, while the agonists produced strong anti-hyperalgesic effects. In our efforts to discover selective 5-HT 7R antagonists or agonists, N-biphenylylmethyl 2- methoxyphenylpiperazinylalkanamides 1 were designed, synthesized, and biologically evaluated against 5-HT7R. Among the synthesized compounds, N-2′-chlorobiphenylylmethyl 2- methoxyphenylpiperazinylpentanamide 1-8 showed the best binding affinity with a Ki value of 8.69 nM and it was verified as a novel antagonist according to functional assays. The compound 1-8 was very selective over 5-HT1DR, 5-HT2AR, 5-HT3R, 5-HT5AR and 5-HT6R and moderately selective over 5-HT1AR, 5-HT1BR and 5-HT2CR. The novel 5-HT7R antagonist 1-8 exhibited an antidepressant effect at a dose of 25 mg/kg in the forced swimming test in mice and showed a U-shaped dose-response curve which typically appears in 5-HT7R antagonists such as SB-269970 and lurasidone.

Potent, orally active inhibitors of lipoprotein-associated phospholipase A2: 1-(biphenylmethylamidoalkyl)-pyrimidones

A series of 1-(biphenylmethylamidoalkyl)-pyrimidones has been designed as nanomolar inhibitors of recombinant lipoprotein-associated phospholipase A2 with high potency in whole human plasma. 5-(Pyrazolylmethyl) derivative 16 and 5-(methoxypyrimidinylmethyl) derivative 27 demonstrated excellent pharmacodynamic profiles which correlated well with their pharmacokinetic effects.

Indole sPLA2 inhibitors

A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA2mediated release of fatty acids for treatment of inflammatory diseases such as septic shock.