1924-77-2

Basic information

• Product Name: 2-PHENYLBENZYLAMINE HYDROCHLORIDE
• Synonyms: 2-PHENYLBENZYLAMINE;2-PHENYLBENZYLAMINE HYDROCHLORIDE;[1,1'-BIPHENYL]-2-YLMETHANAMINE;2-Phenylbenzylamine ,98%;Biphenyl-2-ylMethanaMine hydrochloride;2-AMinoMethylbiphenyl;Biphenyl-2-MethanaMine;(Biphenyl-2-yl)methylamine, 2-Phenylbenzylamine
• CAS NO: 1924-77-2
• Molecular Formula: C₁₃H₁₃N
• Molecular Weight: 183.25
• Mol File: 1924-77-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 106°C 1mm
• Flash Point: 165.9 °C
• Appearance: /
• Density: 1,06 g/cm3
• Vapor Pressure: 0.000108mmHg at 25°C
• Refractive Index: 1.594
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8.97±0.10(Predicted)
• CAS DataBase Reference: 2-PHENYLBENZYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYLBENZYLAMINE HYDROCHLORIDE(1924-77-2)
• EPA Substance Registry System: 2-PHENYLBENZYLAMINE HYDROCHLORIDE(1924-77-2)

Safety Data

• Hazard Codes: C,Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 1924-77-2(Hazardous Substances Data)

Usage

General Description

2-Phenylbenzylamine hydrochloride is a chemical compound that belongs to the group of organic compounds called anilines. It is a white to off-white crystalline powder, and it is used as a reactant in the synthesis of various pharmaceuticals and other organic compounds. 2-PHENYLBENZYLAMINE HYDROCHLORIDE is also utilized in the production of dyes and pigments. It is considered to be a mild irritant to the skin and eyes, and it should be handled with caution. Additionally, 2-phenylbenzylamine hydrochloride is not known to have any significant environmental concerns or hazards.

InChI:InChI=1/C13H13N/c14-10-12-8-4-5-9-13(12)11-6-2-1-3-7-11/h1-9H,10,14H2

Upstream product

• 24973-49-7 biphenyl-2-carbonitrile 
• 123-51-3 i-Amyl alcohol 
• 2042-37-7 o-cyanobromobenzene 
• 3959-05-5 2-bromobenzylamine 
• 98-80-6 phenylboronic acid 
• 4387-36-4 2-iodobenzonitrile 
• 187884-94-2 N-(2-phenyl-phenylmethyl)-phthalimide 
• 1203-68-5 2-Phenylbenzaldehyde 
• 1924-78-3 N-2-Biphenylylmethyl-2-biphenylylmethylen-amin 

Downstream Products

• 914646-89-2 (E)-methyl 3-(2-(2-phenylbenzyl)-1-oxoisoindolin-6-yl)acrylate 
• 914647-58-8 tert-butyl 2-(2-(2-phenylbenzyl)-1-oxoisoindolin-6-yloxy)acetate 
• 1219808-13-5 1-(biphenyl-2-ylmethyl)-2-ethyl-1H-pyrrole 
• 1189819-47-3 C₁₆H₁₄ClN₅ 
• 442689-74-9 2-(isothiocyanatom-ethyl)-1,1’-biphenyl 
• 1489288-15-4 1-(4-chlorophenoxyacetyl)-4-(2-phenylbenzyl)-thiosemicarbazide 
• 486-25-9 9-fluorenone 
• 84-15-1 o-terphenyl 
• 229-87-8 phenanthridine 
• 13737-31-0 N-methyl-2-aminomethylbiphenyl 
• 1203-68-5 2-Phenylbenzaldehyde 

Relevant articles and documents

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Preparation of phenanthridines from N-(o-arylbenzyl)trifluoromethanesulfonamides with 1,3-diiodo-5,5-dimethylhydantoin

Treatment of N-(o-arylbenzyl)trifluoromethanesulfonamides with 1,3-diiodo-5,5-dimethylhydantoin in 1,2-dichloroethane under irradiation with a tungsten lamp, followed by the reaction with tBuOK gave the corresponding 6-arylphenanthridines and 6-unsubstituted phenanthridines in good to moderate yields, respectively. The reaction proceeds through an oxidative cyclization onto the aromatic ring by sulfonamidyl radicals formed from the N-iodosulfonamides. The present reaction is a one-pot method for the preparation of both 6-arylphenanthridines and 6-unsubstituted phenanthridines from N-(o-arylbenzyl)trifluoromethanesulfonamides under transition-metal-free conditions.

Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression

5-HT7 receptor (5-HT7R) is a promising target for the treatment of depression and neuropathic pain. 5-HT7R antagonists exhibited antidepressant effects, while the agonists produced strong anti-hyperalgesic effects. In our efforts to discover selective 5-HT 7R antagonists or agonists, N-biphenylylmethyl 2- methoxyphenylpiperazinylalkanamides 1 were designed, synthesized, and biologically evaluated against 5-HT7R. Among the synthesized compounds, N-2′-chlorobiphenylylmethyl 2- methoxyphenylpiperazinylpentanamide 1-8 showed the best binding affinity with a Ki value of 8.69 nM and it was verified as a novel antagonist according to functional assays. The compound 1-8 was very selective over 5-HT1DR, 5-HT2AR, 5-HT3R, 5-HT5AR and 5-HT6R and moderately selective over 5-HT1AR, 5-HT1BR and 5-HT2CR. The novel 5-HT7R antagonist 1-8 exhibited an antidepressant effect at a dose of 25 mg/kg in the forced swimming test in mice and showed a U-shaped dose-response curve which typically appears in 5-HT7R antagonists such as SB-269970 and lurasidone.