1257420-22-6

Basic information

• Product Name: (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (2R)-2-hydroxy-2-(4-methoxyphenyl)butanoate
• CAS NO: 1257420-22-6
• Molecular Weight: 348.483
• Mol File: 1257420-22-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (2R)-2-hydroxy-2-(4-methoxyphenyl)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (2R)-2-hydroxy-2-(4-methoxyphenyl)butanoate(1257420-22-6)
• EPA Substance Registry System: (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (2R)-2-hydroxy-2-(4-methoxyphenyl)butanoate(1257420-22-6)

Safety Data

• Hazardous Substances Data: 1257420-22-6(Hazardous Substances Data)

Upstream product

• 120926-91-2 (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (4-methoxyphenyl)(oxo)acetate 
• 557-20-0 diethylzinc 

Downstream Products

• 1258305-06-4 C₁₁H₁₄O₄ 

Relevant articles and documents

The stereoselective synthesis of 2-aryl-2-hydroxybutanoic acid via menthyl chiral auxiliaries

In the presence of titanium(IV) tetraethoxide ((EtO)4Ti), menthyl arylglyoxylates are prepared by transesterification of ethyl arylglyoxylates and natural (-)-(1R,2S,5R)-menthol. Using menthyl as a chiral auxiliary, the corresponding novel (R)-menthyl 2-aryl-2-hydroxybutanoates are synthesized by the addition of Et2Zn with menthyl arylglyoxylates. The structures of the products are characterized by IR and 1H- and 13C-NMR spectroscopy, mass spectrometry, and elemental analysis. The diastereoselectivities are analyzed by HPLC. The addition reactions are completed with good yields and high diastereoisomeric excess (de up to 95%), and, after hydrolysis, the (R)-2-aryl-2-hydroxybutanoic acids are obtained with high optical purities.