120926-91-2

Basic information

• Product Name: (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (4-methoxyphenyl)(oxo)acetate
• Synonyms: (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (4-methoxyphenyl)(oxo)acetate
• CAS NO: 120926-91-2
• Molecular Weight: 318.413
• Mol File: 120926-91-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (4-methoxyphenyl)(oxo)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (4-methoxyphenyl)(oxo)acetate(120926-91-2)
• EPA Substance Registry System: (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (4-methoxyphenyl)(oxo)acetate(120926-91-2)

Safety Data

• Hazardous Substances Data: 120926-91-2(Hazardous Substances Data)

Upstream product

• 2216-51-5 (-)-menthol 
• 40140-16-7 ethyl (p-methoxyphenyl)oxoacetate 
• 100-07-2 4-methoxy-benzoyl chloride 
• 14271-83-1 4-methoxybenzoyl cyanide 

Downstream Products

• 91121-61-8 2-(4-methoxyphenyl)-2-hydroxypropanoic acid 
• 91121-61-8 2-hydroxy-2-(4-methoxy-phenyl)-propionic acid 
• 1257420-22-6 (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (2R)-2-hydroxy-2-(4-methoxyphenyl)butanoate 

Relevant articles and documents

The stereoselective synthesis of 2-aryl-2-hydroxybutanoic acid via menthyl chiral auxiliaries

In the presence of titanium(IV) tetraethoxide ((EtO)4Ti), menthyl arylglyoxylates are prepared by transesterification of ethyl arylglyoxylates and natural (-)-(1R,2S,5R)-menthol. Using menthyl as a chiral auxiliary, the corresponding novel (R)-menthyl 2-aryl-2-hydroxybutanoates are synthesized by the addition of Et2Zn with menthyl arylglyoxylates. The structures of the products are characterized by IR and 1H- and 13C-NMR spectroscopy, mass spectrometry, and elemental analysis. The diastereoselectivities are analyzed by HPLC. The addition reactions are completed with good yields and high diastereoisomeric excess (de up to 95%), and, after hydrolysis, the (R)-2-aryl-2-hydroxybutanoic acids are obtained with high optical purities.