1257434-64-2Relevant academic research and scientific papers
Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling
Chen, Huifen,Volgraf, Matthew,Do, Steven,Kolesnikov, Aleksandr,Shore, Daniel G.,Verma, Vishal A.,Villemure, Elisia,Wang, Lan,Chen, Yong,Hu, Baihua,Lu, Ai-Jun,Wu, Guosheng,Xu, Xiaofeng,Yuen, Po-Wai,Zhang, Yamin,Erickson, Shawn D.,Dahl, Martin,Brotherton-Pleiss, Christine,Tay, Suzanne,Ly, Justin Q.,Murray, Lesley J.,Chen, Jun,Amm, Desiree,Lange, Wienke,Hackos, David H.,Reese, Rebecca M.,Shields, Shannon D.,Lyssikatos, Joseph P.,Safina, Brian S.,Estrada, Anthony A.
, p. 3641 - 3659 (2018)
Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel expressed in sensory neurons where it functions as an irritant sensor for a plethora of electrophilic compounds and is implicated in pain, itch, and respiratory disease. To s
HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1
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Page/Page column 156-157, (2010/12/29)
Certain heterocyclic amide compounds are described. The compounds may be used in pharmaceutical compositions and methods for treating disease states, disorders, and conditions mediated by TRPA1 activity, such as pain, arthritis, itch, cough, asthma, or inflammatory bowel disease.
