125744-05-0

Basic information

• Product Name: 4'-acetamino-2-methyl-4-tosylamino-diphenylsulfone
• Synonyms: 4'-acetamino-2-methyl-4-tosylamino-diphenylsulfone
• CAS NO: 125744-05-0
• Molecular Weight: 458.559
• Mol File: 125744-05-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4'-acetamino-2-methyl-4-tosylamino-diphenylsulfone(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-acetamino-2-methyl-4-tosylamino-diphenylsulfone(125744-05-0)
• EPA Substance Registry System: 4'-acetamino-2-methyl-4-tosylamino-diphenylsulfone(125744-05-0)

Safety Data

• Hazardous Substances Data: 125744-05-0(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 125743-99-9 4'-acetamino-4-amino-2-methyl-diphenylsulfone 
• 99-52-5 2-methyl-4-nitro-benzenamine 
• 125743-96-6 4'-acetamino-2-methyl-4-nitro-diphenylsulfone 
• 13290-74-9 1-chloro-2-methyl-4-nitrobenzene 

Downstream Products

• 101513-47-7 4'-acetamino-2-methyl-4-(N-n-propyl-tosylamino)-diphenylsulfone 
• 101513-21-7 4'-amino-2-methyl-4-n-propylamino-diphenylsulfone 

Relevant articles and documents

Preparation and biological activity of new substituted antimalarial diaminodiphenylsulfones

Starting from 4,4'-diamino-diphenylsulfone (DDS) as a lead structure, new 2-substituted analogues as well as new 2-substituted 4-alkylamino-4'-amino diphenylsulfones have been designed and synthesized in different ways. This has led to compounds the inhibitory activity of which against 7,8-dihydropteroic acid synthase of plasmodia and mycobacteria is clearly superior to that of sulfadoxine and in most cases to that of DDS. Of special interest is 4'-amino-4-n-propylamino-2-methyl-diphenylsulfone. Together with inhibitors of 7,8-dihydrofolate reductase in vitro and in vivo it possesses a marked synergistic inhibitory activity against plasmodia. In contrast to DDS in doses up to 200 mg/kg p.o. (cat) no methemoglobin formation is observed. The compound has been selected for further studies.