13290-74-9

Usage

Chemical Properties

white to light yellow crystal powder

InChI:InChI=1/C7H6ClNO2/c1-5-4-6(9(10)11)2-3-7(5)8/h2-4H,1H3

Upstream product

• 64-17-5 ethanol 
• 51123-59-2 3-chloro-2-methyl-6-nitrobenzenamine 
• 95-49-8 2-methylchlorobenzene 
• 99-52-5 2-methyl-4-nitro-benzenamine 
• 7697-37-2 nitric acid 
• 99-08-1 1-methyl-3-nitrobenzene 
• 7782-50-5 chlorine 
• 638-03-9 m-toluidine hydrochloride 
• 110-86-1 pyridine 
• 420134-77-6 2-chloro-5-nitro-toluene-4-sulfinic acid 

Downstream Products

• 50741-92-9 2-methyl-4-nitroanisole 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 455-88-9 5-nitro-2-fluorotoluene 
• 34662-36-7 3-chloro-5-nitrobenzoic acid 
• 18905-50-5 2-chloro-1-methyl-3,5-dinitrobenzene 
• 176512-23-5 3-methyl-4-(4-nitrophenylthio)aniline 
• 7149-75-9 3-methyl-4-chloroaniline 
• 125743-96-6 4'-acetamino-2-methyl-4-nitro-diphenylsulfone 
• 52427-01-7 2-(bromomethyl)-1-chloro-4-nitrobenzene 
• 21232-49-5 bis-(4-chloro-3-methyl-phenyl)-diazene 
• 108-44-1 1-amino-3-methylbenzene 
• 56961-88-7 N-(4-chloro-3-methylphenyl)acetamide 
• 106310-21-8 3-methyl-4-(4-((trifluoromethyl)thio)phenyl)oxy-1-nitrobenzene 
• 27080-45-1 4-nitro-2-methyl-N-(β-aminoethyl) aniline monohydrochloride 

Relevant academic research and scientific papers

Nitration of deactivated aromatic compounds via mechanochemical reaction

A variety of deactivated arenes were nitrated to their corresponding nitro derivatives in excellent yields under high-speed ball milling condition using Fe(NO3)3·9H2O/P2O5 as nitrating reagent. A radical involved mechanism was proposed for this facial, eco-friendly, safe, and effective nitration reaction.

Preparation method of 2-chlorine-5-nitro-methylbenzene

The invention relates to preparation of fine chemical intermediates, in particular to a preparation method of 2-chlorine-5-nitro-methylbenzene. The method comprises the steps that chlorine serves as achloride agent, transition metal or a corresponding sal

Method for synthesizing nitrobenzene ether from 2-amino-5-nitrotoluene

The invention relates to the technical field of pharmaceutical synthesis and particularly relates to a method for synthesizing nitrobenzene ether from 2-amino-5-nitrotoluene. The method comprises thefollowing steps: reacting by virtue of 2-amino-5-nitroto

Reaction of dimethyldioxirane with aniline hydrohalides

Oxidation of aromatic amine hydrohalides (aniline hydrochloride, hydrobromide, and hydrofluoride; 4-methylaniline hydrochloride and hydrobromide; 3-methylaniline and N,N-diethylaniline hydrochlorides) with dimethyldioxirane was studied. The product composition was analyzed in relation to the reactant ratio.

A novel method for the nitration of simple aromatic compounds

Simple aromatic compounds such as benzene, alkylbenzenes, halogenobenzenes, and some disubstituted benzenes are nitrated in excellent yields with high regioselectivity under mild conditions using zeolite β as a catalyst and a stoichiometric quantity of nitric acid and acetic anhydride. The zeolite can be recycled, and the only byproduct is acetic acid, which can be separated easily from the nitration product by distillation; the process is inexpensive and represents an attractive method for the clean synthesis of a range of nitroaromatic compounds. For example, nitration of toluene gives a quantitative yield of mononitrotoluenes, of which 79% is 4-nitrotoluene; fluorobenzene gives a quantitative yield of mononitro compounds, of which 94% is 4-nitrofluorobenzene; and 2-fluorotoluene gives a 96% yield of mononitro products, of which 90% is the 5-nitro isomer and 10% is the 4-nitro isomer.

Preparation and biological activity of new substituted antimalarial diaminodiphenylsulfones

Starting from 4,4'-diamino-diphenylsulfone (DDS) as a lead structure, new 2-substituted analogues as well as new 2-substituted 4-alkylamino-4'-amino diphenylsulfones have been designed and synthesized in different ways. This has led to compounds the inhibitory activity of which against 7,8-dihydropteroic acid synthase of plasmodia and mycobacteria is clearly superior to that of sulfadoxine and in most cases to that of DDS. Of special interest is 4'-amino-4-n-propylamino-2-methyl-diphenylsulfone. Together with inhibitors of 7,8-dihydrofolate reductase in vitro and in vivo it possesses a marked synergistic inhibitory activity against plasmodia. In contrast to DDS in doses up to 200 mg/kg p.o. (cat) no methemoglobin formation is observed. The compound has been selected for further studies.