125744-14-1

Basic information

• Product Name: Benzenamine, 3-methyl-4-[(4-nitrophenyl)sulfonyl]-N-propyl-
• CAS NO: 125744-14-1
• Molecular Formula: C16H18N2O4S
• Molecular Weight: 334.396
• Mol File: 125744-14-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzenamine, 3-methyl-4-[(4-nitrophenyl)sulfonyl]-N-propyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 3-methyl-4-[(4-nitrophenyl)sulfonyl]-N-propyl-(125744-14-1)
• EPA Substance Registry System: Benzenamine, 3-methyl-4-[(4-nitrophenyl)sulfonyl]-N-propyl-(125744-14-1)

Safety Data

• Hazardous Substances Data: 125744-14-1(Hazardous Substances Data)

Upstream product

• 125744-11-8 2-methyl-4'-nitro-4-tosylamino-diphenylsulfone 
• 125744-09-4 2-methyl-4-acetylamino-4'-nitrodiphenyl sulphone 
• 125744-10-7 4-amino-2-methyl-4'-nitro-diphenylsulfone 
• 125744-08-3 4-acetamino-2-methyl-benzenesulfinic acid 
• 62374-67-8 4-acetamino-2-methyl-benzenesulfonyl chloride 
• 133-78-8 4-amino-2-methylbenzenesulphonic acid 
• 176512-28-0 2-methyl-4-(N-propyl-N-tosyl)-amino-4'-nitrodiphenyl sulfide 
• 176512-26-8 4-Methyl-N-[3-methyl-4-(4-nitro-phenylsulfanyl)-phenyl]-benzenesulfonamide 
• 176512-23-5 3-methyl-4-(4-nitrophenylthio)aniline 
• 125744-12-9 2-methyl-4'-nitro-4-(N-n-propyl-tosylamino)-diphenylsulfone 

Downstream Products

• 101513-21-7 4'-amino-2-methyl-4-n-propylamino-diphenylsulfone 

Relevant articles and documents

New antifolate 4,4'-diaminodiphenyl sulfone substituted 2,4-diamino-5-benzylpyrimidines. Proof of their dual mode of action and autosynergism

New 4,4'-diaminodiphenylsulfone substituted 2,4-diamino-5-benzylpyrimidines were synthesized. These compounds are highly active inhibitors of both bacterial dihydrofolate reductase (DHFR) and dihydropteroic acid synthase (SYN). The simultaneous inhibition

Preparation and biological activity of new substituted antimalarial diaminodiphenylsulfones

Starting from 4,4'-diamino-diphenylsulfone (DDS) as a lead structure, new 2-substituted analogues as well as new 2-substituted 4-alkylamino-4'-amino diphenylsulfones have been designed and synthesized in different ways. This has led to compounds the inhibitory activity of which against 7,8-dihydropteroic acid synthase of plasmodia and mycobacteria is clearly superior to that of sulfadoxine and in most cases to that of DDS. Of special interest is 4'-amino-4-n-propylamino-2-methyl-diphenylsulfone. Together with inhibitors of 7,8-dihydrofolate reductase in vitro and in vivo it possesses a marked synergistic inhibitory activity against plasmodia. In contrast to DDS in doses up to 200 mg/kg p.o. (cat) no methemoglobin formation is observed. The compound has been selected for further studies.