62374-67-8

Usage

Uses

Used in Organic Synthesis:
Benzenesulfonyl chloride, 4-(acetylamino)-2-methyl(9CI) is used as a reagent in organic synthesis for the preparation of various organic compounds. Its high reactivity and the presence of functional groups allow it to participate in numerous chemical reactions, contributing to the synthesis of complex organic molecules.
Used in Pharmaceutical Manufacturing:
In the pharmaceutical industry, Benzenesulfonyl chloride, 4-(acetylamino)-2-methyl(9CI) is utilized as a reagent for the preparation of pharmaceutical compounds. Its ability to introduce the acetylamino group into other molecules makes it a useful coupling agent in the development and production of drugs with specific therapeutic properties.
Used in Drug Development:
Due to its potential to react with a variety of functional groups, Benzenesulfonyl chloride, 4-(acetylamino)-2-methyl(9CI) is valued in drug development for its versatility. It can be employed to create new drug candidates with desired pharmacological activities, contributing to the advancement of novel therapeutic agents.
Overall, Benzenesulfonyl chloride, 4-(acetylamino)-2-methyl(9CI) is a versatile and valuable chemical compound with applications in organic synthesis, pharmaceutical manufacturing, and drug development, owing to its reactivity and functional group diversity.

InChI:InChI=1/C9H10ClNO3S/c1-6-5-8(11-7(2)12)3-4-9(6)15(10,13)14/h3-5H,1-2H3,(H,11,12)

Upstream product

• 133-78-8 4-amino-2-methylbenzenesulphonic acid 
• 537-92-8 3-Methylacetanilide 

Downstream Products

• 125744-08-3 4-acetamino-2-methyl-benzenesulfinic acid 
• 6324-76-1 5-benzoylamino-toluene-2-sulfonic acid amide 
• 857617-21-1 5-acetylamino-4-bromo-toluene-2-sulfonic acid amide 
• 23202-51-9 5-hydroxy-toluene-2-sulfonic acid amide 
• 94109-57-6 4-amino-2-methylbenzenesulfonamide 
• 125744-13-0 4-(N-n-hexyl-tosylamino)-2-methyl-4'-nitro-diphenylsulfone 
• 125744-12-9 2-methyl-4'-nitro-4-(N-n-propyl-tosylamino)-diphenylsulfone 
• 125744-11-8 2-methyl-4'-nitro-4-tosylamino-diphenylsulfone 
• 125744-16-3 4-cyclohexylamino-2-methyl-4'-nitro-diphenylsulfone 
• 125744-17-4 4-cyclopentylamino-2-methyl-4'-nitro-diphenylsulfone 
• 125744-15-2 4-n-hexylamino-2-methyl-4'-nitro-diphenylsulfone 
• 125744-09-4 2-methyl-4-acetylamino-4'-nitrodiphenyl sulphone 
• 125744-14-1 2-methyl-4'-nitro-4-n-propylamino-diphenylsulfone 
• 125744-18-5 2-methyl-4'-nitro-4-i-propylamino-diphenylsulfone 

Relevant academic research and scientific papers

USP30 INHIBITORS

The application relates to phenyl- or naphthylsulfonamide derivatives of the structural formula (I). The compounds are described as inhibitors of USP30 (ubiquitin specific peptidase 30) useful for the treatment of conditions involving mitochondrial defects including neurodegenerative diseases such as Alzheimer's and Parkinson's or a neoplastic disease such as leukemia.

NOVEL ANTITHROMBOTIC SUBSTITUTED PYRROLIDINONES, THE PRODUCTION AND USE THEREOF IN THE FORM OF MEDICAMENTS

The invention relates to novel substituted pyrrolidines of general formula (I), wherein A, X, B and R1 to R9 are such as defined in the claim 1, and to the tautomers, enantiomers, diastereomers, mixtures and the salts thereof, in par

ANTIPROLIFERATIVE 2-(SULFO-PHENYL)-AMINOTHIAZOLE DERIVATIVES

Aminothiazole compounds substituted with sulfur-containing groups are represented by the Formula (I), and their pharmaceutically acceptable salts, prodrugs, active metabolites, and pharmaceutically acceptable salts of said metabolites are described. These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.

Carboxylic acid amides having antithrombotic activity

Compounds with antithrombotic activity and factor Xa-inhibiting activity of the general formula: Exemplary are: (1) (L)-2-(5-carbamimidoyl-2-hydroxy-phenyl)-N-[3-methyl-4-(2-aminocarbonyl-pyrrolidin-1-yl-carbonyl)-phenyl]-acetamide, (2) 2-(5-carbamimidoyl

New processes for the synthesis of 2,6-dichloro-3- methylaniline-Ph-UL-14C and methyl 6-chloroanthranilate-Ph-UL-14C

Two new processes were developed for the synthesis of 2,6-dichloro-3-methylaniline-Ph-UL-14C (1), a key intermediate in the synthesis of a DowElanco experimental product presently being considered for commercialization. Both processes afford product in much higher yields than that previously reported in the literature. One of the processes was subsequenly applied to the synthesis of methyl 6-chloroanthranilate-Ph-14C (12), used as an intermediate for a second potential product.

Preparation and biological activity of new substituted antimalarial diaminodiphenylsulfones

Starting from 4,4'-diamino-diphenylsulfone (DDS) as a lead structure, new 2-substituted analogues as well as new 2-substituted 4-alkylamino-4'-amino diphenylsulfones have been designed and synthesized in different ways. This has led to compounds the inhibitory activity of which against 7,8-dihydropteroic acid synthase of plasmodia and mycobacteria is clearly superior to that of sulfadoxine and in most cases to that of DDS. Of special interest is 4'-amino-4-n-propylamino-2-methyl-diphenylsulfone. Together with inhibitors of 7,8-dihydrofolate reductase in vitro and in vivo it possesses a marked synergistic inhibitory activity against plasmodia. In contrast to DDS in doses up to 200 mg/kg p.o. (cat) no methemoglobin formation is observed. The compound has been selected for further studies.