1257443-64-3

Basic information

• Product Name: (R)-tert-butyl 4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoate
• Synonyms: (R)-tert-butyl 4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoate
• CAS NO: 1257443-64-3
• Molecular Weight: 442.35
• Mol File: 1257443-64-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-tert-butyl 4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-tert-butyl 4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoate(1257443-64-3)
• EPA Substance Registry System: (R)-tert-butyl 4-(1-(4-bromophenyl)-4-ethoxy-4-oxobutan-2-ylamino)-4-oxobutanoate(1257443-64-3)

Safety Data

• Hazardous Substances Data: 1257443-64-3(Hazardous Substances Data)

Upstream product

• 331763-75-8 (R)-4-(4-bromophenyl)-3-((tert-butoxycarbonyl)amino)butanoic acid 
• 1257446-29-9 (R)-ethyl 4-(4-bromophenyl)-3-(tert-butoxycarbonylamino)butanoate 
• 15026-17-2 succinic acid mono-tert-butyl ester 
• 1257446-30-2 (R)-ethyl 3-amino-4-(4-bromophenyl)butanoate hydrochloride 

Downstream Products

• 1257443-65-4 (R)-tert-butyl 4-(4-ethoxy-1-(5'-fluoro-2'-methoxybiphenyl-4-yl)-4-oxobutan-2-ylamino)-4-oxobutanoate 

Relevant articles and documents

METHOD OF TREATING CONTRAST-INDUCED NEPHROPATHY

The present invention provides the use of a neutral endopeptidase inhibitor, in the manufacture of a medicament for the treatment, amelioration and/or prevention of contrast-induced nephropathy. The invention also relates to the use of a compound of Formula I: wherein R1, R2, R3, R5, X, A3, B1, s and n are defined herein, for the treatment, amelioration and/or prevention of contrast-induced nephropathy. The present invention further provides a combination of pharmacologically active agents for use in the treatment, amelioration and/or prevention of contrast-induced nephropathy.