1257516-22-5Relevant academic research and scientific papers
Design and optimization of new piperidines as renin inhibitors
Corminboeuf, Olivier,Bezenon, Olivier,Grisostomi, Corinna,Remeň, ?ubo?,Richard-Bildstein, Sylvia,Bur, Daniel,Prade, Lars,Hess, Patrick,Strickner, Panja,Fischli, Walter,Steiner, Beat,Treiber, Alexander
, p. 6286 - 6290 (2010)
The discovery of a new series of piperidine-based renin inhibitors is described herein. SAR optimization upon the P3 renin sub-pocket is described, leading to the discovery of 9 and 41, two bioavailable renin inhibitors orally active at low doses in a tra
