125756-95-8

Basic information

• Product Name: 4-BROMO-3-ETHOXYANILINE HYDROCHLORIDE
• Synonyms: 4-BROMO-3-ETHOXYANILINE HCL;4-BROMO-3-ETHOXYANILINE HYDROCHLORIDE;4-bromo-3-ethoxyaniline;Benzenamine, 4-bromo-3-ethoxy- (9CI);3-ETHOXYANILINE-4-BROMOHCL;3-ETHOXY-4-BROMO ANILINE
• CAS NO: 125756-95-8
• Molecular Formula: C₈H₁₀BrNO
• Molecular Weight: 252.54
• Product Categories: ETHOXY;Fluorobenzene;Aniline;Miscellaneous;Anilines, Amides & Amines;Anisoles, Alkyloxy Compounds & Phenylacetates;Bromine Compounds
• Mol File: 125756-95-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 286.4 °C at 760 mmHg
• Flash Point: 127 °C
• Appearance: /
• Density: 1.455 g/cm³
• Vapor Pressure: 0.000243mmHg at 25°C
• PKA: 3.52±0.10(Predicted)
• CAS DataBase Reference: 4-BROMO-3-ETHOXYANILINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-3-ETHOXYANILINE HYDROCHLORIDE(125756-95-8)
• EPA Substance Registry System: 4-BROMO-3-ETHOXYANILINE HYDROCHLORIDE(125756-95-8)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36
• Hazardous Substances Data: 125756-95-8(Hazardous Substances Data)

Usage

Uses

4-Bromo-3-ethoxyaniline Hydrochloride is used as a reactant in the preparation of anilinoquinolinecarboxamides as CSF-1R kinase inhibitors.

InChI:InChI=1/C8H10BrNO.ClH/c1-2-11-8-5-6(10)3-4-7(8)9;/h3-5H,2,10H2,1H3;1H

Upstream product

• 554-84-7 meta-nitrophenol 
• 52427-05-1 2-bromo-5-nitrophenol 
• 423165-33-7 1-bromo-2-ethoxy 4-nitrobenzene 

Downstream Products

• 1352619-74-9 N-[4-(2-{[2-ethoxy-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-2-(4-fluorophenyl)acetamide 
• 1352620-17-7 4-(2-{[2-ethoxy-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]amino}[1,2,4]triazolo-[1,5-a]pyridin-6-yl)-N-(4-fluorobenzyl)benzamide 
• 1600515-58-9 C₁₉H₁₆BrN₃O 
• 850727-45-6 C₁₁H₁₁BrN₄O₂ 
• 1041853-51-3 1-(2-amino-5-bromo-4-ethoxyphenyl)ethanone 
• 1041853-22-8 6-bromo-7-ethoxy-4-hydroxycinnoline-3-carboxylic acid 

Relevant articles and documents

LACTAMS AS INHIBITORS OF ROCK

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

SUBSTITUTED TRIAZOLOPYRIDINES

The present invention relates to substituted triazolopyridine compounds of general formula (I) : in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease of uncontrolled cell growth, proliferation and/or survival as well as to the use of intermediate compounds for the preparation of said compounds.