1257641-91-0Relevant academic research and scientific papers
Design and synthesis of novel NO-donor-ferulic acid hybrids as potential antiatherosclerotic drug candidates a
Li, Nian-Guang,Wang, Rong,Shi, Zhi-Hao,Tang, Yu-Ping,Li, Bao-Quan,Wang, Zhen-Jiang,Song, Shu-Lin,Qian, Li-Hua,Wei, Li,Yang, Jian-Ping,Yao, Li-Juan,Xi, Jun-Zuan,Xu, Jia,Feng, Feng,Qian, Da-Wei,Duan, Jin-Ao
, p. 405 - 415 (2012/05/05)
Novel NO-donor-ferulic acid hybrids were designed and synthesized through a symbiotic approach using ferulic acid and three different NO-donating groups, such as nitric ester, 4-hydroxyl-3-phenylfuroxan, and 4-hydroxymethyl-3- phenylsulfonylfuroxan. Antioxidant, nitric oxide release, and vasodilator properties studies showed that the target phenylsulfonylfuroxan 14, especially 14c, while keeping the antioxidant activity, showed more NO release activity and vasodilating activity than isosorbide dinitrate (ISDN). Thus, 14c may be considered a novel potent anti-atherosclerosis drug candidate.
