125775-13-5Relevant academic research and scientific papers
Concise synthesis of pentenyl phenyl acrylic acid
Sun, Dequn,Lai, Pengxiang,Xie, Weidong,Deng, Jingen,Jiang, Yaozhong
, p. 2989 - 2994 (2008/02/12)
Pentenyl phenyl acrylic acid is a structural unit of pepticinnamin E, a natural product and a bisubstrate inhibitor of FPTase. In this article, a new synthetic strategy was developed to prepare pentenyl phenyl acrylic acid with high stereoselectivity and
Synthesis and in vitro evaluation of the farnesyltransferase inhibitor pepticinnamin E
Hinterding, Klaus,Hagenbuch, Patrizia,Re?tey, Janos,Waldmann, Herbert
, p. 227 - 236 (2007/10/03)
The farnesyltransferase inhibitor pepticinnamin E was synthesized and shown to have the S configuration at the central, non-proteinogenic amino acid. Using a recombinant yeast farnesyltransferase the biological activity of the natural product and structur
Synthesis and in vitro evaluation of the Ras farnesyltransferase inhibitor pepticinnamin E
Hinterding, Klaus,Hagenbuch, Patrizia,Retey, Janos,Waldmann, Herbert
, p. 1236 - 1239 (2007/10/03)
A modularly built bisubstrate inhibitor, the natural product pepticinnamin E (shown on the right) was synthesized for the first time. In the case of in vitro assays it inhibits the enzyme farnesyltransferase with respect to both the peptide substrate and farnesylpyrophosohate (K1 = 30 and 8 μM, respectively). The inhibitory activity is decisively influenced by the central tripeptide unit and the absolute configuration of the non-proteinogenic amino acid incorporated therein.
Structure of WS9326A, a Novel Tachykinin Antagonist from a Streptomyces
Shigematsu, Nobuharu,Hayashi, Kenichi,Kayakiri, Natsuko,Takase, Shigehiro,Hashimoto, Masashi,Tanaka, Hirokazu
, p. 170 - 175 (2007/10/02)
A novel tachykinin antagonist WS9326A was isolated from Streptomyces violaceoniger no. 9326.It is an acylated macrocyclic heptapeptide lactone consisting of L-Thr, (E)-dehydro-N-methyltyrosine ((E)-ΔMeTyr), L-Leu, D-Phe, L-allo-Thr, L-Asn, L-Ser, and 3-2
