128839-49-6Relevant articles and documents
An Easy-to-Machine Electrochemical Flow Microreactor: Efficient Synthesis of Isoindolinone and Flow Functionalization
Folgueiras-Amador, Ana A.,Philipps, Kai,Guilbaud, Sébastien,Poelakker, Jarno,Wirth, Thomas
, p. 15446 - 15450 (2017/11/10)
Flow electrochemistry is an efficient methodology to generate radical intermediates. An electrochemical flow microreactor has been designed and manufactured to improve the efficiency of electrochemical flow reactions. With this device only little or no supporting electrolytes are needed, making processes less costly and enabling easier purification. This is demonstrated by the facile synthesis of amidyl radicals used in intramolecular hydroaminations to produce isoindolinones. The combination with inline mass spectrometry facilitates a much easier combination of chemical steps in a single flow process.
Synthesis and in vitro evaluation of the farnesyltransferase inhibitor pepticinnamin E
Hinterding, Klaus,Hagenbuch, Patrizia,Re?tey, Janos,Waldmann, Herbert
, p. 227 - 236 (2007/10/03)
The farnesyltransferase inhibitor pepticinnamin E was synthesized and shown to have the S configuration at the central, non-proteinogenic amino acid. Using a recombinant yeast farnesyltransferase the biological activity of the natural product and structur
Synthesis and in vitro evaluation of the Ras farnesyltransferase inhibitor pepticinnamin E
Hinterding, Klaus,Hagenbuch, Patrizia,Retey, Janos,Waldmann, Herbert
, p. 1236 - 1239 (2007/10/03)
A modularly built bisubstrate inhibitor, the natural product pepticinnamin E (shown on the right) was synthesized for the first time. In the case of in vitro assays it inhibits the enzyme farnesyltransferase with respect to both the peptide substrate and farnesylpyrophosohate (K1 = 30 and 8 μM, respectively). The inhibitory activity is decisively influenced by the central tripeptide unit and the absolute configuration of the non-proteinogenic amino acid incorporated therein.
Palladium-Assisted (Z)-(E) Isomerization of Styrenes
Giles, Robin G. F.,Son, Vanessa R. Lee,Sargent, Melvyn V.
, p. 777 - 781 (2007/10/02)
It is shown that treatment of stereoisomeric mixtures of styrenes with a catalytic amount of bis(acetonitrile)dichloropalladium(II) achieves smooth stereoisomerization of the (Z)-isomers to the (E)-isomers.