1258000-10-0

Basic information

• Product Name: C₂₆H₃₂F₂N₂O₂
• Synonyms: C₂₆H₃₂F₂N₂O₂
• CAS NO: 1258000-10-0
• Molecular Weight: 442.549
• Mol File: 1258000-10-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₆H₃₂F₂N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₃₂F₂N₂O₂(1258000-10-0)
• EPA Substance Registry System: C₂₆H₃₂F₂N₂O₂(1258000-10-0)

Safety Data

• Hazardous Substances Data: 1258000-10-0(Hazardous Substances Data)

Upstream product

• 27064-94-4 4,4'-difluorobenzhydryl chloride 
• 336191-17-4 tert-butyl 2,8-diazaspiro[4.5]decane-2-carboxylate 

Downstream Products

• 1258000-11-1 C₂₁H₂₄F₂N₂ 

Relevant articles and documents

Design, syntheses, and SAR of 2,8-diazaspiro[4.5]decanones as T-type calcium channel antagonists

It was hypothesized that an appropriately substituted 2,8-diazaspiro[4.5] decan-1-one could effectively approximate a 5-feature T-type pharmacophore model published in the literature. Compounds were designed and synthesized to test our hypothesis and were found to be potent T-type calcium channel inhibitors with modest selectivity over L-type calcium channels. The synthesis and SAR of the series is described.