1258013-09-0

Basic information

• Product Name: 1-bromo-4-(2,2-difluoro-2-(phenylsulfonyl)ethyl)benzene
• Synonyms: 1-bromo-4-(2,2-difluoro-2-(phenylsulfonyl)ethyl)benzene
• CAS NO: 1258013-09-0
• Molecular Weight: 361.207
• Mol File: 1258013-09-0.mol

Chemical Properties

• CAS DataBase Reference: 1-bromo-4-(2,2-difluoro-2-(phenylsulfonyl)ethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-4-(2,2-difluoro-2-(phenylsulfonyl)ethyl)benzene(1258013-09-0)
• EPA Substance Registry System: 1-bromo-4-(2,2-difluoro-2-(phenylsulfonyl)ethyl)benzene(1258013-09-0)

Safety Data

• Hazardous Substances Data: 1258013-09-0(Hazardous Substances Data)

Upstream product

• 589-15-1 1-bromomethyl-4-bromobenzene 
• 536975-50-5 [difluoro(phenylsulfonyl)methyl](trimethyl)silane 

Downstream Products

• 84750-93-6 1,1-difluoro-2-(4-bromophenyl)ethene 

Relevant articles and documents

Nucleophilic (phenylsulfonyl)difluoromethylation of alkyl halides using PhSO2CF2SiMe3: Preparation of gem-difluoroalkenes and trifluoromethyl compounds

Nucleophilic (phenylsulfonyl)difluoromethylation of both alkyl iodides and bromides was successfully accomplished by using CsF/15-crown-5 as an initiating system in DME, and the amount of 15-crown-5 was found to be critical to the yield of the product. The prepared (phenylsulfonyl)difluoromethylated alkanes were converted into gem-difluoroalkenes by a base-mediated 1,2-elimination reaction, and the latter species could be further transformed into trifluoromethyl compounds in the presence of KF/18-crown-6 or TBAF.