536975-50-5

Usage

Uses

Used in Pharmaceutical Industry:
[Difluoro(phenylsulfonyl)methyl]trimethylsilane is used as a reagent for the synthesis of various pharmaceuticals due to its ability to protect and functionalize different functional groups in organic molecules. Its unique structure and properties contribute to the development of new drugs with enhanced efficacy and safety profiles.
Used in Agrochemical Industry:
In the agrochemical industry, [difluoro(phenylsulfonyl)methyl]trimethylsilane is used as a reagent for the production of agrochemicals. Its role in protecting and functionalizing functional groups in organic molecules aids in the development of more effective and targeted agrochemical products.
Used in Specialty Chemicals Industry:
[Difluoro(phenylsulfonyl)methyl]trimethylsilane is also used as a reagent in the synthesis of specialty chemicals. Its versatility as a trimethylsilylating agent and a building block for complex organic compounds makes it a valuable asset in this industry, enabling the creation of innovative and high-performance specialty chemicals.
Used in Medicinal Chemistry Research:
[difluoro(phenylsulfonyl)Methyl]triMethyl-Silane is used as a research tool in medicinal chemistry for the development of new drugs. Its ability to protect and functionalize various functional groups in organic molecules makes it a valuable asset in the design and synthesis of novel drug candidates with improved pharmacological properties.
Overall, [difluoro(phenylsulfonyl)methyl]trimethylsilane is a valuable and versatile chemical reagent with significant synthetic and medicinal applications across various industries.

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 80351-58-2 [(bromodifluoromethyl)sulfonyl]benzene 
• 108-98-5 thiophenol 
• 115262-01-6 [bromo(difluoro)methyl]-trimethyl-silane 
• 873-55-2 sodium benzenesulfonate 
• 66-99-9 β-naphthaldehyde 
• 1535-65-5 difluoromethyl phenyl sulfone 
• 78031-08-0 [(bromodifluoromethyl)sulfanyl]benzene 
• 536975-49-2 phenyl (trimethylsilyl)difluoromethyl sulfide 

Downstream Products

• 861721-49-5 (E)-1,1-difluoro-4-phenyl-1-(phenylsulfonyl)but-3-en-2-ol 
• 122590-87-8 2,2-difluoro-1-(4-methoxyphenyl)-2-(phenylsulfonyl)ethan-1-ol 
• 871504-64-2 2,2-difluoro-1-(naphthalen-2-yl)-2-(phenylsulfonyl)ethan-1-ol 
• 1017593-09-7 C₂₇H₃₁F₂NO₃S 
• 1017593-02-0 C₂₇H₃₁F₂NO₃S 
• 1017593-03-1 C₂₇H₃₁F₂NO₃S 
• 1017593-00-8 C₃₀H₂₉F₂NO₃S 
• 1017593-01-9 C₃₀H₂₉F₂NO₃S 
• 1017593-13-3 C₃₀H₂₉F₂NO₃S 
• 1017593-12-2 C₃₀H₂₉F₂NO₃S 
• 1017593-06-4 C₂₆H₂₉F₂NO₃S 
• 1017593-07-5 C₂₄H₂₅F₂NO₃S 
• 1017593-08-6 C₂₄H₂₅F₂NO₃S 
• 1017593-10-0 C₃₀H₃₉F₂NO₄SSi 

Relevant academic research and scientific papers

Direct Electrophilic (Benzenesulfonyl)Difluoromethylthiolation with a Shelf-Stable Reagent

The (benzenesulfonyl)difluoromethylsulfanyl (PhSO2CF2S) group is a valuable substituent with specific properties which can provide access to new applications of fluoroalkylthiolated compounds. Direct introduction of this moiety can be performed by in an electrophilic manner by using a new shelf-stable reagent, namely a (benzenesulfonyl)difluoromethanesulfenamide. Furthermore, mild magnesium-mediated reduction of the PhSO2CF2S group leads to a facile synthesis of difluoromethylthiolated molecules and their deuterated analogs. Chameleon-like reactivity: (Benzenesulfonyl)difluoromethanesulfenamide was developed as a new, shelf-stable reagent for the introduction of the PhSO2CF2S group into organic molecules (see scheme). The versatility of the PhSO2 moiety also provides an entry into reductive deuterations.

Nucleophilic (Phenylsulfonyl/arylthio)difluoromethylation of Aldehydes with TMSCF2Br: A Three-Component Strategy

An efficient method for nucleophilic (phenylsulfonyl/arylthio)difluoromethylation of aldehydes with TMSCF2Br was developed. The reaction proceeds through in situ generation of difluorocarbene, which is captured by PhSO2Na or ArSNa to

An easier and quicker access to (benzenesulfonyl)difluoromethanesulfenamide reagent

(Benzenesulfonyl)difluoromethanesulfenamide (PhSO2-BB12H) is an interesting reagent to lead to various fluoroalkylselenotated molecules. This compound is obtained from [(benzenesulfonyl)difluoromethyl]trimethylsilane. Herein, a new process in two steps, w

Reactions of sulfur- and phosphorus-substituted fluoroalkylating silicon reagents with imines and enamines under acidic conditions

Nucleophilic fluoroalkylation reactions of imines and enamines with α-phenylthio, α-phenylsulfonyl, and α-diethylphosphoryl substituted fluorinated silanes have been investigated. The reactions are promoted by hydrofluoric acid generated in situ from pota

Copper-mediated fluoroalkylation reactions with [(phenylsulfonyl)- difluoromethyl]trimethylsilane: Synthesis of PhSO2CF 2-containing allenes and alkynes

Copper-mediated (phenylsulfonyl)difluoromethylation of propargyl chlorides and alkynyl halides with PhSO2CF2TMS reagent was successfully achieved to give PhSO2CF2-containing allenes and alkynes, respectively. It is believed that the in situ formed PhSO 2CF2Cu species is involved in the present (phenylsulfonyl)difluoromethylation reactions. Georg Thieme Verlag Stuttgart · New York.

Syntheses of mono-, di-, and trifluorinated styrenic monomers

Concise syntheses of gram quantities of three fluorinated -methylstyrenic monomers suitable for polymerisation studies are disclosed, all based on the use of reasonably priced commercially available starting materials and reagents. Georg Thieme Verlag Stuttgart New York.

Stereoselective synthesis of α-difluoromethyl-β-amino alcohols via nucleophilic difluoromethylation with Me3SiCF2SO2Ph

A facile synthesis of anti-α-(difluoromethyl)-β-amino alcohols was accomplished by using a nucleophilic difluoromethylation strategy with Me3SiCF2SO2Ph reagent. Good to excellent chemical yields as well as modest to good d

Nucleophilic difluoromethylation of carbonyl compounds using TMSCF 2SO2Ph and Mg0-mediated desulfonylation

A new nucleophilic difluoromethylation chemistry using fluoride-induced (phenylsulfonyl)difluoromethylation with TMSCF2SO2Ph followed by the magnesium-metal-mediated desulfonylation has been achieved. This methodology is compatible w

Preparation of tri- and difluoromethylsilanes via an unusual magnesium metal-mediated reductive tri- and difluoromethylation of chlorosilanes using tri- and difluoromethyl sulfides, sulfoxides, and sulfones

A new and efficient method for the preparation of tri- and difluoromethylsilanes using magnesium metal-mediated reductive tri- and difluoromethylation of chlorosilanes is reported using tri- and difluoromethyl sulfides, sulfoxides, and sulfones. The byproduct of the process is diphenyl disulfide. Since phenyl trifluoromethyl sulfone, sulfoxide, and sulfide are readily prepared from trifluoromethane (CF3H) and diphenyl disulfide, the method can be considered to be catalytic in diphenyl disulfide for the preparation of (trifluoromethyl)trimethylsilane (TMS-CF3) from non-ozone-depleting trifluoromethane.