536975-50-5

Basic information

• Product Name: [difluoro(phenylsulfonyl)Methyl]triMethyl-Silane
• Synonyms: [difluoro(phenylsulfonyl)Methyl]triMethyl-Silane
• CAS NO: 536975-50-5
• Molecular Formula: C₁₀H₁₄F₂O₂SSi
• Molecular Weight: 264.3642664
• Mol File: 536975-50-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 96-97 °C(Press: 1 Torr)
• Appearance: /
• Density: 1.162±0.06 g/cm3(Predicted)
• CAS DataBase Reference: [difluoro(phenylsulfonyl)Methyl]triMethyl-Silane(CAS DataBase Reference)
• NIST Chemistry Reference: [difluoro(phenylsulfonyl)Methyl]triMethyl-Silane(536975-50-5)
• EPA Substance Registry System: [difluoro(phenylsulfonyl)Methyl]triMethyl-Silane(536975-50-5)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 536975-50-5(Hazardous Substances Data)

Usage

General Description

[Difluoro(phenylsulfonyl)methyl]trimethylsilane is a chemical compound with the molecular formula C11H15F2OSi. It is a silane compound that is used as a reagent in organic synthesis. Its unique structure and properties make it valuable in the production of various pharmaceuticals, agrochemicals, and specialty chemicals. [difluoro(phenylsulfonyl)Methyl]triMethyl-Silane has potential applications in the field of medicinal chemistry, particularly in the development of new drugs. As a trimethylsilylating reagent, it can be used for the protection and functionalization of various functional groups in organic molecules. Additionally, it serves as a versatile building block for the synthesis of complex organic compounds. Overall, [difluoro(phenylsulfonyl)methyl]trimethylsilane is a valuable and versatile chemical reagent with significant synthetic and medicinal applications.

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 80351-58-2 [(bromodifluoromethyl)sulfonyl]benzene 
• 115262-01-6 [bromo(difluoro)methyl]-trimethyl-silane 
• 873-55-2 sodium benzenesulfonate 
• 66-99-9 β-naphthaldehyde 
• 1535-65-5 difluoromethyl phenyl sulfone 
• 78031-08-0 [(bromodifluoromethyl)sulfanyl]benzene 
• 536975-49-2 phenyl (trimethylsilyl)difluoromethyl sulfide 
• 108-98-5 thiophenol 

Downstream Products

• 871504-64-2 2,2-difluoro-1-(naphthalen-2-yl)-2-(phenylsulfonyl)ethan-1-ol 

Relevant articles and documents

Direct Electrophilic (Benzenesulfonyl)Difluoromethylthiolation with a Shelf-Stable Reagent

The (benzenesulfonyl)difluoromethylsulfanyl (PhSO2CF2S) group is a valuable substituent with specific properties which can provide access to new applications of fluoroalkylthiolated compounds. Direct introduction of this moiety can be performed by in an electrophilic manner by using a new shelf-stable reagent, namely a (benzenesulfonyl)difluoromethanesulfenamide. Furthermore, mild magnesium-mediated reduction of the PhSO2CF2S group leads to a facile synthesis of difluoromethylthiolated molecules and their deuterated analogs. Chameleon-like reactivity: (Benzenesulfonyl)difluoromethanesulfenamide was developed as a new, shelf-stable reagent for the introduction of the PhSO2CF2S group into organic molecules (see scheme). The versatility of the PhSO2 moiety also provides an entry into reductive deuterations.

An easier and quicker access to (benzenesulfonyl)difluoromethanesulfenamide reagent

(Benzenesulfonyl)difluoromethanesulfenamide (PhSO2-BB12H) is an interesting reagent to lead to various fluoroalkylselenotated molecules. This compound is obtained from [(benzenesulfonyl)difluoromethyl]trimethylsilane. Herein, a new process in two steps, w

Copper-mediated fluoroalkylation reactions with [(phenylsulfonyl)- difluoromethyl]trimethylsilane: Synthesis of PhSO2CF 2-containing allenes and alkynes

Copper-mediated (phenylsulfonyl)difluoromethylation of propargyl chlorides and alkynyl halides with PhSO2CF2TMS reagent was successfully achieved to give PhSO2CF2-containing allenes and alkynes, respectively. It is believed that the in situ formed PhSO 2CF2Cu species is involved in the present (phenylsulfonyl)difluoromethylation reactions. Georg Thieme Verlag Stuttgart · New York.