1258064-80-0

Basic information

• Product Name: N-benzyl-N-4-toluenesulfonyl-(2,6-dimethylphenyl)ethynylamine
• Synonyms: N-benzyl-N-4-toluenesulfonyl-(2,6-dimethylphenyl)ethynylamine
• CAS NO: 1258064-80-0
• Molecular Weight: 389.518
• Mol File: 1258064-80-0.mol

Chemical Properties

• CAS DataBase Reference: N-benzyl-N-4-toluenesulfonyl-(2,6-dimethylphenyl)ethynylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-N-4-toluenesulfonyl-(2,6-dimethylphenyl)ethynylamine(1258064-80-0)
• EPA Substance Registry System: N-benzyl-N-4-toluenesulfonyl-(2,6-dimethylphenyl)ethynylamine(1258064-80-0)

Safety Data

• Hazardous Substances Data: 1258064-80-0(Hazardous Substances Data)

Upstream product

• 1123-56-4 2,6-dimethylbenzaldehyde 
• 608-28-6 2,6-dimethyliodobenzene 
• 205885-39-8 N-benzyl-N-ethynyl-4-methyl-benzenesulfonamide 
• 1576-37-0 N-benzyl-p-toluenesulfonamide 
• 1391469-79-6 (2,2-dibromoethenyl)-2,6-dimethylbenzene 

Relevant articles and documents

Keteniminium ion-initiated cascade cationic polycyclization

A novel and efficient keteniminium-initiated cationic polycyclization is reported. This reaction, which only requires triflic acid or bistriflimide as promoters, affords a straightforward entry to polycyclic nitrogen heterocycles possessing up to three co

Cationic polycyclization of ynamides: Building up molecular complexity

Polycyclization reactions are among the most efficient synthetic tools for the synthesis of complex, polycyclic molecules in a single operation from simple starting materials. We report in this manuscript a full account on the discovery and development of a novel cationic polycyclization from readily available ynamides. Simple activation of these building blocks under acidic conditions enables the generation of highly reactive activated keteniminium ions, which triggers an unprecedented cationic polycyclization yielding highly substituted polycyclic nitrogen heterocycles possessing up to seven fused cycles and three contiguous stereocenters.

Chemo- and stereoselective synthesis of fluorinated enamides from ynamides in HF/pyridine: Second-generation approach to potent ureas bioisosteres

(E)- and (Z)-α-fluoroenamides could be easily prepared with high levels of chemo- and regioselectivities by hydrofluorination of readily available ynamides with HF/pyridine. The scope and limitations of this new process for the hydrofluorination of ynamides, as well as the stability of the resulting α-fluoroenamides, have been extensively studied. Theoretical calculations at the MP2 and B3LYP levels of theory showed that the resulting fluoroenamides exhibit geometrical and electronic properties that partially mirror those of ureas, therefore demonstrating that the hydrofluorination of ynamides provides a general, straightforward, and user-friendly approach to bioisosteres of ureas, potent building blocks for biological studies and medicinal chemistry.

Copper-mediated selective cross-coupling of 1,1-dibromo-1-alkenes and heteronucleophiles: Development of general routes to heterosubstituted alkynes and alkenes

Efficient and general procedures for the cross-coupling of 1,1-dibromoalkenes and N-, O-, and P-nucleophiles are reported. Fine-tuning of the reaction conditions allows for either site-selective, double, or alkynylative cross-coupling, therefore providing

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