125812-06-8

Basic information

• Product Name: N-(5,6,7,8-tetrahydro-7-methyl-2,5-dioxo-2H-1-benzopyran-3-yl)benzamide
• Synonyms: N-(5,6,7,8-tetrahydro-7-methyl-2,5-dioxo-2H-1-benzopyran-3-yl)benzamide
• CAS NO: 125812-06-8
• Molecular Weight: 297.31
• Mol File: 125812-06-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-(5,6,7,8-tetrahydro-7-methyl-2,5-dioxo-2H-1-benzopyran-3-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5,6,7,8-tetrahydro-7-methyl-2,5-dioxo-2H-1-benzopyran-3-yl)benzamide(125812-06-8)
• EPA Substance Registry System: N-(5,6,7,8-tetrahydro-7-methyl-2,5-dioxo-2H-1-benzopyran-3-yl)benzamide(125812-06-8)

Safety Data

• Hazardous Substances Data: 125812-06-8(Hazardous Substances Data)

Upstream product

• 495-69-2 Hippuric Acid 
• 4341-24-6 5-methylcyclohexan-1,3-dione 
• 14036-06-7 diethoxymethyl acetate 
• 106551-63-7 2-((dimethylamino)methylene)-5-methylcyclohexane-1,3-dione 
• 60777-96-0 (Z)-4-(ethoxymethylene)-2-phenyloxazol-5(4H)-one 
• 56952-04-6 methyl 2-N-benzoylamino-3-N,N-dimethylamino-2-propenoate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 122-51-0 orthoformic acid triethyl ester 
• 149-73-5 trimethyl orthoformate 
• 107872-68-4 2-benzoylamino-3-chloro-acrylic acid 

Downstream Products

• 1373124-55-0 N-(5,6,7,8-tetrahydro-6-methyl-8-oxonaphthalen-2-yl)-benzamide 
• 1611491-72-5 N-(5-hydroxy-7-methyl-2-oxo-2H-chromen-3-yl)-benzamide 

Relevant articles and documents

Synthesis of 5,6,7,8-tetrahydro-2H-1-benzopyran-2,5-diones and 1,5-dihydro-2H-pyrrol-2-ones

The use of 2-benzoylamino-3-chloropropenoic acid in the synthesis of 5,6,7,8-tetrahydro-2H-1-benzopyran-2,5-diones and 1,5-dihydro-2H-pyrrol-2-ones is reported.

4-ETHOXYMETHYLENE-2-PHENYL-5(4H)-OXAZOLONE AS A SYNTHON FOR THE SYNTHESIS OF SOME 2H-PYRAN-2-ONES

Treatment of 4-ethoxymethylene-2-phenyl-5(4H)-oxazolone with activated methylene compounds under acidic or basic conditions leads to 2H-pyran-2-ones and fused pyran-2-ones.On the other hand, methyl (3-benzoylamino-5-methoxycarbonyl-2-oxo-2H-pyran-6-yl)acetate (4) has also been prepared by a one-pot synthesis from dimethyl 1,3-acetone dicarboxylate, diethoxymethyl acetate, hippuric acid and acetic anhydride.

Methyl 2-Benzoylamino-3-dimethylaminopropenoate in the Synthesis of Fused Pyranones. The Synthesis of Derivatives of Tetrahydro-2H-1-benzopyran-2-one, Isomeric 2H-Naphtholpyran-2-one and 3H-Naphthopyran-3-one, Pyranobenzopyran-2,5-dione, and 7H-Pyranopyrimi...

Methyl 2-benzoylamino-3-dimethylaminopropenoate (1) reacts with carbocyclic and heterocyclic 1,3-diketones or potential 1,3-diketones, such as 1,3-cyclohexanediones 2-4, and 4-hydroxy-2H-1-benzopyran-2-one derivative 17, in acetic acid to afford the corresponding 3-benzoylamino substituted 5-oxo-5,6,7,8-tetrahydro-2H-1-benzopyran-2-ones 5-7, and 2H,5H-pyranobenzopyran-2,5-dione derivative 18. 1-Naphthol (12) and 2-naphthol (13) produce the isomeric 2H-naphthopyran-2-one (14) and 3H-naphthopyran-3-one (15) derivatives, respectively.Ethyl cyclopentanone-2-carboxylate (8) and ethyl cyclohexanone-2-carboxylate (9) do not react under these conditions, while in polyphosphoric acid the cyclisation of the reagent 1 is taking place to give 4-dimethylaminomethylene-2-phenyl-5(4H)-oxazolone (10). 4,6-Dihydroxypyrimidine derivative 19 affords in acetic acid the noncyclized intermediate 20, which can be further transformed in polyphosphoric acid into 7H-pyranopyrimidin-7-one derivative 21.