1258203-31-4Relevant articles and documents
COMPOSITIONS AND METHODS FOR INHIBITION OF CATHEPSINS
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, (2017/03/14)
This present disclosure is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin L, cathepsin K, and/or cathepsin B, will be therapeutically useful.
Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L
Chavarria, Gustavo E.,Horsman, Michael R.,Arispe, Wara M.,Kishore Kumar,Chen, Shen-En,Strecker, Tracy E.,Parker, Erica N.,Chaplin, David J.,Pinney, Kevin G.,Trawick, Mary Lynn
, p. 568 - 572 (2013/02/23)
Kinetic analysis of the mode of inhibition of cathepsin L by KGP94, a lead compound from a privileged library of functionalized benzophenone thiosemicarbazone derivatives, demonstrated that it is a time-dependent, reversible, and competitive inhibitor of
