1258239-34-7Relevant academic research and scientific papers
Synthesis of Conformationally Constrained Esters and Amines by Pd-Catalyzed α-Arylation of Hindered Substrates
Martin, Anthony,Vors, Jean-Pierre,Baudoin, Olivier
, p. 3941 - 3945 (2016)
The α-arylation of sterically hindered silyl ketene acetals (SKAs) with sterically hindered aryl bromides occurs efficiently using Pd[P(t-Bu)3]2 as the optimal catalyst and ZnF2 as a promoter. Less sensitive P(t-Bu)3
Palladium-catalyzed β arylation of carboxylic esters
Renaudat, Alice,Jean-GUrard, Ludivine,Jazzar, Rodolphe,Kefalidis, Christos E.,Clot, Eric,Baudoin, Olivier
supporting information; experimental part, p. 7261 - 7265 (2010/11/18)
Alter ego: In the presence of an appropriate palladium(0) catalyst, carboxylic esters underwent β arylation instead of the more common α-arylation reaction with aryl halides containing an ortho electronegative substituent (see scheme; Cy = cyclohexyl). An asymmetric version of the reaction gave the product with an enantiomeric ratio of up to 77:23.
