1258274-77-9

Upstream product

• 1258274-70-2 9-benzyl-6-chloro-7,8-dihydropurine 
• 100-44-7 benzyl chloride 
• 1928-76-3 9-benzyl-6-chloro-9H-purine 
• 100-39-0 benzyl bromide 

Relevant academic research and scientific papers

Regioselective and facile synthesis of 7,9-dialkyl-8-oxopurines from 7,9-dialkyl-7,8-dihydropurines: Total synthesis of heteromines i and J

A novel protocol for the synthesis of 6-halo-8-oxo-7,8-dihydro-9H-purines based on the oxidation of 7,9-dialkyl-7,8-dihydro-9H-purines has been developed. The presented methodology was used as a key step in the synthesis of heteromines I and J. Georg Thie

Selective synthesis of 7-substituted purines via 7,8-dihydropurines

A simple and efficient protocol for the preparation of 7-substituted purines is described. 6- and 2,6-Dihalopurines were N9-tritylated and then transformed to 7,8-dihydropurines by DIBAL-H. Subsequent N 7-alkylation followed by N9-trityl deprotection with trifluoroacetic acid was accompanied by spontaneous reoxidation, which led to the 7-substituted purines at 55 - 88% overall isolated yields.