1258327-35-3Relevant academic research and scientific papers
Synthesis and biological evaluation of [D-lysine]8cyclosporin A analogs as potential anti-HCV agents
Scribner, Andrew,Houck, David,Huang, Zhuhui,Mosier, Sarah,Peel, Michael,Scorneaux, Bernard
scheme or table, p. 6542 - 6546 (2010/12/20)
An efficient synthesis of [d-lysine]8cyclosporin A has been developed. Several analogs of [d-lysine]8cyclosporin A have been synthesized and show promising anti-HCV activity, particularly compounds 39 and 43, which each exhibit an anti-HCV EC50 200 nM, and are each ≥50-fold less immunosuppressive than cyclosporin A.
