159391-94-3Relevant academic research and scientific papers
Synthesis and characterization of bodipy-FL-cyclosporine a as a substrate for multidrug resistance-linked P-glycoprotein (ABCB1)
Sajid, Andaleeb,Raju, Natarajan,Lusvarghi, Sabrina,Vahedi, Shahrooz,Swenson, Rolf E.,Ambudkar, Suresh V.
, p. 1013 - 1023 (2019)
Fluorescent conjugates of drugs can be used to study cellular functions and pharmacology. These compounds interact with proteins as substrates or inhibitors, helping in the development of unique fluorescence-based methods to study in vivo localization and
Synthesis and biological evaluation of [D-lysine]8cyclosporin A analogs as potential anti-HCV agents
Scribner, Andrew,Houck, David,Huang, Zhuhui,Mosier, Sarah,Peel, Michael,Scorneaux, Bernard
scheme or table, p. 6542 - 6546 (2010/12/20)
An efficient synthesis of [d-lysine]8cyclosporin A has been developed. Several analogs of [d-lysine]8cyclosporin A have been synthesized and show promising anti-HCV activity, particularly compounds 39 and 43, which each exhibit an anti-HCV EC50 200 nM, and are each ≥50-fold less immunosuppressive than cyclosporin A.
Cyclosporin A: Regioselective Ring Opening and Fragmentation Reactions via Thioamides. A Route to Semisynthetic Cyclosporins
Eberle, Marcel K.,Jutzi-Eme, Anne-Marie,Nuninger, Francois
, p. 7249 - 7258 (2007/10/02)
Cyclosporin A (1a) served as the starting material for the semisynthetic preparation of a variety of novel cyclosporins.Acetylcyclosporin A (2) was treated with Lawesson's reagent.From the reaction mixture, three novel acetylated thioamides were isolated:
