1258328-80-1

Basic information

• Product Name: dimethyl 2-({cyclohexyl[(8-methoxy-2-oxo-2H-chromen-3-yl)carbonyl]amino}carbonyl)-2-butenedioate
• Synonyms: dimethyl 2-({cyclohexyl[(8-methoxy-2-oxo-2H-chromen-3-yl)carbonyl]amino}carbonyl)-2-butenedioate
• CAS NO: 1258328-80-1
• Molecular Weight: 471.464
• Mol File: 1258328-80-1.mol

Chemical Properties

• CAS DataBase Reference: dimethyl 2-({cyclohexyl[(8-methoxy-2-oxo-2H-chromen-3-yl)carbonyl]amino}carbonyl)-2-butenedioate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 2-({cyclohexyl[(8-methoxy-2-oxo-2H-chromen-3-yl)carbonyl]amino}carbonyl)-2-butenedioate(1258328-80-1)
• EPA Substance Registry System: dimethyl 2-({cyclohexyl[(8-methoxy-2-oxo-2H-chromen-3-yl)carbonyl]amino}carbonyl)-2-butenedioate(1258328-80-1)

Safety Data

• Hazardous Substances Data: 1258328-80-1(Hazardous Substances Data)

Upstream product

• 931-53-3 Cyclohexyl isocyanide 
• 2555-20-6 8-methoxy-2-oxo-2H-chromene-3-carboxylic acid 
• 762-42-5 dimethyl acetylenedicarboxylate 

Downstream Products

• 1258328-78-7 dimethyl 2-(tert-butylamino)-5-{cyclohexyl[(8-methoxy-2-oxo-2H-chromen-3-yl)carbonyl]amino}-3,4-furandicarboxylate 

Relevant articles and documents

Synthesis of 2-(alkylamino)-5-{alkyl[(2-oxo-2H-chromen-3-yl)carbonyl]amino} -3,4-furandicarboxylates using a multi-component reaction in water

A simple synthesis of 2-(alkylamino)-5-{alkyl[(2-oxo-2H-chromen-3-yl) carbonyl]amino}-3,4-furandicarboxylates via a one-pot multi-component reaction is described. The reactive 1:1 zwitterionic intermediate generated from the addition of isocyanides to dialkyl acetylenedicarboxylates was trapped at room temperature by coumarin-3-carboxylic acids prepared in situ from a 2-hydroxy aromatic aldehyde and Meldrum's acid to afford the title compounds in good to excellent yields.