125846-81-3Relevant academic research and scientific papers
A Short and Efficient Approach to Pyrrolo[2,1- a ]isoquinoline and Pyrrolo[2,1-a]benzazepine Derivatives
Jebali, Khaoula,Planchat, Aurélien,Amri, Hassen,Mathé-Allainmat, Monique,Lebreton, Jacques
, p. 1502 - 1517 (2016)
A Br?nsted acid promoted intramolecular Friedel-Crafts cyclization of β-benzoyl- and β-acetylpyrrol-2(5H)-one derivatives tethered via nitrogen to an electron-rich arene nucleus is developed. Using this efficient methodology, various pyrrolo[2,1-a]isoquinoline and pyrrolo[2,1-a]benzazepine derivatives are prepared in a two-step sequence starting from readily available ethyl (Z)-3-bromomethyl-4-oxo-4-phenylbut-2-enoate or ethyl (Z)-3-bromomethyl-4-oxopent-2-enoate.
Ruthenium hydride/Bronsted acid-catalyzed tandem isomerization/N-acyliminium cyclization sequence for the synthesis of tetrahydro-β-carbolines
Hansen, Casper L.,Clausen, Janie W.,Ohm, Ragnhild G.,Ascic, Erhad,Le Quement, Sebastian T.,Tanner, David,Nielsen, Thomas E.
, p. 12545 - 12565 (2014/01/17)
This paper describes an efficient tandem sequence for the synthesis of 1,2,3,4-tetrahydro-β-carbolines (THBCs) relying on a ruthenium hydride/Bronsted acid-catalyzed isomerization of allylic amides to N-acyliminium ion intermediates which are trapped by a
