1258498-71-3Relevant academic research and scientific papers
Organocatalytic C-H bond arylation of aldehydes to bis-heteroaryl ketones
Toh, Qiao Yan,McNally, Andrew,Vera, Silvia,Erdmann, Nico,Gaunt, Matthew J.
supporting information, p. 3772 - 3775 (2013/04/24)
An organocatalytic aldehyde C-H bond arylation process for the synthesis of complex heteroaryl ketones has been developed. By exploiting the inherent electrophilicity of diaryliodonium salts, we have found that a commercial N-heterocyclic carbene catalyst promotes the union of heteroaryl aldehydes and these heteroaromatic electrophile equivalents in good yields. This straightforward catalytic protocol offers access to ketones bearing a diverse array of arene and heteroarene substituents that can subsequently be converted into molecules displaying structural motifs commonly found in medicinal agents.
Palladium-catalyzed carbonylative C-H activation of heteroarenes
Wu, Xiao-Feng,Anbarasan, Pazhamalai,Neumann, Helfried,Beller, Matthias
supporting information; experimental part, p. 7316 - 7319 (2010/11/05)
Not only carbonylation: The first carbonylative cross-coupling reactions towards ketones using C-H activation have been developed. Various heteroarenes, such as oxazoles, thiazoles, and imidazoles were used as coupling partners in this methodology. DBU =
