62667-25-8

Basic information

• Product Name: BENZOOXAZOLE-2-CARBALDEHYDE
• Synonyms: BENZO[D]OXAZOLE-2-CARBALDEHYDE;BENZOOXAZOLE-2-CARBALDEHYDE;RARECHEM AK ML 0183;2-Benzoxazolecarboxaldehyde (6CI, 9CI);2-Benzoxazolecarboxaldehyde
• CAS NO: 62667-25-8
• Molecular Formula: C₈H₅NO₂
• Molecular Weight: 147.13
• Product Categories: ALDEHYDE
• Mol File: 62667-25-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 276.3 °C at 760 mmHg
• Flash Point: 120.9 °C
• Appearance: /
• Density: 1.322 g/cm³
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 0.17±0.10(Predicted)
• CAS DataBase Reference: BENZOOXAZOLE-2-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZOOXAZOLE-2-CARBALDEHYDE(62667-25-8)
• EPA Substance Registry System: BENZOOXAZOLE-2-CARBALDEHYDE(62667-25-8)

Safety Data

• Hazardous Substances Data: 62667-25-8(Hazardous Substances Data)

Upstream product

• 95-21-6 2-methyl-1,3-benzoxazole 
• 80352-44-9 1-benzooxazol-2-ylmethyl-pyridinium; iodide 
• 27383-86-4 benzoxazole-2-carboxylic acid methyl ester 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 614-80-2 2-(acetylamino)phenol 
• 95-55-6 2-amino-phenol 

Downstream Products

• 1258498-71-3 benzo[d]oxazol-2-yl(o-tolyl)methanone 
• 1327274-44-1 benzo[d]oxazol-2-yl(3-bromophenyl)methanone 
• 1258498-75-7 benzo[d]oxazol-2-yl(4-methoxy phenyl)methanone 
• 1426082-76-9 (benzoxazol-2-yl)(3-methylphenyl)methanone 
• 28458-93-7 benzo[d]oxazol-2-yl(phenyl)methanone 
• 1426083-10-4 C₂₂H₁₅N₃O₄S 
• 1402598-34-8 N-(1,3-benzoxazol-2-yl(phenyl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide 
• 68700-36-7 2-[4-benzooxazol-2-ylmethylene-2-(2,4-dinitro-phenyl)-5-methyl-2,4-dihydro-pyrazol-3-ylidenemethyl]-3-ethyl-benzooxazolium; iodide 
• 68700-34-5 2-[4-benzooxazol-2-ylmethylene-2-(2,4-dinitro-phenyl)-5-methyl-2,4-dihydro-pyrazol-3-ylidenemethyl]-1-ethyl-quinolinium; iodide 
• 68700-33-4 2-[4-benzooxazol-2-ylmethylene-2-(2,4-dinitro-phenyl)-5-methyl-2,4-dihydro-pyrazol-3-ylidenemethyl]-1-ethyl-pyridinium; iodide 
• 68700-32-3 2-(4-benzooxazol-2-ylmethylene-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-ylidenemethyl)-3-ethyl-benzooxazolium; iodide 
• 68700-31-2 2-(4-benzooxazol-2-ylmethylene-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-ylidenemethyl)-1-ethyl-quinolinium; iodide 
• 68748-40-3 2-(4-benzooxazol-2-ylmethylene-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-ylidenemethyl)-1-ethyl-pyridinium; iodide 
• 68700-43-6 4-benzooxazol-2-ylmethylene-2-(2,4-dinitro-phenyl)-5-methyl-2,4-dihydro-pyrazol-3-one 

Relevant articles and documents

Iodine-catalyzed oxidative annulation: Facile synthesis of pyrazolooxepinopyrazolones: Via methyl azaarene sp3C-H functionalization

An iodine-catalyzed methyl azaarene sp3 C-H functionalization has been developed for the synthesis of a seven-membered O-heterocyclic architecture containing three different heterocyclic aromatic hydrocarbons. This method can be applied to a wide range of substituted methyl azaarenes and diverse 2,4-dihydro-3H-pyrazol-3-ones, and brings about the efficient preparation of 2,9-dihydrooxepino[2,3-c:6,5-c′]dipyrazol-3(7H)-ones in high yields with the merits of low catalyst loading, good functional group tolerance and metal-free conditions.

Catalytic Aerobic Photo-oxidation of a Methyl Group on a Heterocycle to Produce an Aldehyde via Homolytic C-I Bond Cleavage caused by Irradiation with Visible Light

A new catalytic method was developed for photo-oxidizing the methyl group on aromatic heterocycles such as benzothiazole, benzoxazole, and quinoline to produce the corresponding aldehyde. This is the first report of the metal-free catalytic synthesis of benzothiazole-2-carboxaldehydes using molecular oxygen as the terminal oxidant.

LRRK2 INHIBITORS

Provided herein are compounds that inhibit or partially inhibit the activity of leucine rich repeat kinases. Also provided herein are methods of treatment of CNS disorders comprising administration of inhibitors of leucine rich repeat kinases.