Cas 1258522-89-2,3,4-bis-(4-methoxyphenyl)-selenophene

1258522-89-2

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Basic information

Product Name: 3,4-bis-(4-methoxyphenyl)-selenophene
Synonyms: 3,4-bis-(4-methoxyphenyl)-selenophene
CAS NO:1258522-89-2
Molecular Formula:
Molecular Weight: 343.284
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 3,4-bis-(4-methoxyphenyl)-selenophene(CAS DataBase Reference)
NIST Chemistry Reference: 3,4-bis-(4-methoxyphenyl)-selenophene(1258522-89-2)
EPA Substance Registry System: 3,4-bis-(4-methoxyphenyl)-selenophene(1258522-89-2)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1258522-89-2(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1258522-89-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,8,5,2 and 2 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1258522-89:
(9*1)+(8*2)+(7*5)+(6*8)+(5*5)+(4*2)+(3*2)+(2*8)+(1*9)=172
172 % 10 = 2
So 1258522-89-2 is a valid CAS Registry Number.

1258522-89-2Upstream product

1258522-89-2Downstream Products

1258522-89-2Relevant academic research and scientific papers

Selenophenes: Introducing a New Element into the Core of Non-Steroidal Estrogen Receptor Ligands

Zhang, Silong,Wang, Zhiyong,Hu, Zhiye,Li, Changhao,Tang, Chu,Carlson, Kathryn E.,Luo, Junjie,Dong, Chune,Katzenellenbogen, John A.,Huang, Jian,Zhou, Hai-Bing

, p. 235 - 249 (2017)

The importance of the heterocyclic core elements with peripheral phenolic and alkyl substituents as a dominant structural motif of ligands for the estrogen receptor (ER) has been well recognized. In this study we expanded the structural diversity of core

Rational design and optimization of selenophenes with basic side chains as novel potent selective estrogen receptor modulators (SERMs) for breast cancer therapy

Luo, Junjie,Hu, Zhiye,Xiao, Yuan,Yang, Tongxin,Dong, Chune,Huang, Jian,Zhou, Hai-Bing

, p. 1485 - 1497 (2017/07/25)

To increase the diversity of estrogen receptor (ER) ligands having novel structures and activities, series of selenophene derivatives with a basic side chain (BSC) were synthesized and their biological activity as subtype-selective antagonists for the ER was explored. Compared with the selenophenes without a BSC, most compounds showed an increase in binding affinity, and several compounds displayed enhanced antagonist potency and antiproliferative activity. Especially, compound 16c exhibited excellent transcriptional activity for ERα (IC50 = 13 nM) which made this compound the most potent antagonist for ERα of the whole series and is 66-fold better than the best selenophene compound without a BSC. Moreover, several compounds showed values of IC50 better than that of 4-hydroxytamoxifen in breast cancer MCF-7 cells. The modeling study indicated that the basic side chain might contribute to their increased antagonist potency and antiproliferative activity. These new ligands have the potential to be further developed as novel agents to improve therapeutics that target the estrogen receptor.

Selenophen compound

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Paragraph 0011; 0013; 0014, (2016/10/08)

The invention belongs to the technical field of medicines and in particular discloses a selenophen compound which takes an estrogen receptor as a target point, has resistance to hormone-dependent (positive ER+) breast cancer and also has high inhibitory a

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