1258544-91-0Relevant academic research and scientific papers
Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5
Felts, Andrew S.,Rodriguez, Alice L.,Morrison, Ryan D.,Bollinger, Katrina A.,Venable, Daryl F.,Blobaum, Anna L.,Byers, Frank W.,Thompson Gray, Analisa,Daniels, J. Scott,Niswender, Colleen M.,Jones, Carrie K.,Conn, P. Jeffrey,Lindsley, Craig W.,Emmitte, Kyle A.
, p. 4858 - 4866 (2017)
Based on a hypothesis that an intramolecular hydrogen bond was present in our lead series of picolinamide mGlu5 NAMs, we reasoned that an inactive nicotinamide series could be modified through introduction of a fused heterocyclic core to genera
Bicyclic And Tricyclic Compounds As KAT II Inhibitors
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Page/Page column 36-37, (2010/12/31)
Compounds of Formula X: wherein A, X, Y, Z, R5, R6a, and R6b are as defined herein, and pharmaceutically acceptable salts thereof, are described as useful for the treatment of cognitive deficits associated with schizophrenia and other neurodegenerative and/or neurological disorders in mammals, including humans.
