1258544-91-0Relevant articles and documents
Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5
Felts, Andrew S.,Rodriguez, Alice L.,Morrison, Ryan D.,Bollinger, Katrina A.,Venable, Daryl F.,Blobaum, Anna L.,Byers, Frank W.,Thompson Gray, Analisa,Daniels, J. Scott,Niswender, Colleen M.,Jones, Carrie K.,Conn, P. Jeffrey,Lindsley, Craig W.,Emmitte, Kyle A.
, p. 4858 - 4866 (2017)
Based on a hypothesis that an intramolecular hydrogen bond was present in our lead series of picolinamide mGlu5 NAMs, we reasoned that an inactive nicotinamide series could be modified through introduction of a fused heterocyclic core to genera
