1258545-24-2Relevant articles and documents
Structure-based design of irreversible human KAT II inhibitors: Discovery of new potency-enhancing interactions
Tuttle, Jamison B.,Anderson, Marie,Bechle, Bruce M.,Campbell, Brian M.,Chang, Cheng,Dounay, Amy B.,Evrard, Edelweiss,Fonseca, Kari R.,Gan, Xinmin,Ghosh, Somraj,Horner, Weldon,James, Larry C.,Kim, Ji-Young,McAllister, Laura A.,Pandit, Jayvardhan,Parikh, Vinod D.,Rago, Brian J.,Salafia, Michelle A.,Strick, Christine A.,Zawadzke, Laura E.,Verhoest, Patrick R.
supporting information, p. 37 - 40 (2013/03/14)
A series of aryl hydroxamates recently have been disclosed as irreversible inhibitors of kynurenine amino transferase II (KAT II), an enzyme that may play a role in schizophrenia and other psychiatric and neurological disorders. The utilization of structu