1258632-56-2

Usage

Uses

Used in Pharmaceutical Synthesis:
3-(4-Methoxyphenyl)pyridin-4-aMine is used as a key intermediate in the synthesis of pharmaceuticals for its potential therapeutic applications, particularly in the treatment of neurodegenerative diseases and cancer. Its unique chemical structure and properties contribute to the development of new drugs and biologically active molecules.
Used in Agrochemical Synthesis:
In the agrochemical industry, 3-(4-Methoxyphenyl)pyridin-4-aMine is utilized as a building block in the creation of agrochemicals, contributing to the development of effective and environmentally friendly products for agricultural use.
Used in Organic Synthesis:
3-(4-Methoxyphenyl)pyridin-4-aMine serves as a valuable component in organic synthesis, enabling the production of a wide range of chemical compounds with diverse applications in various industries.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 3-(4-Methoxyphenyl)pyridin-4-aMine is employed as a starting material for the design and synthesis of novel drug candidates, leveraging its chemical properties to explore its potential in treating various medical conditions.

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 19798-77-7 4-amino-3-chloropyridine 
• 5720-07-0 4-methoxyphenylboronic acid 

Relevant academic research and scientific papers

Pd-Catalyzed Suzuki coupling reactions of aryl halides containing basic nitrogen centers with arylboronic acids in water in the absence of added base

The Pd-catalyzed Suzuki coupling reactions of a series of aryl chlorides and aryl bromides containing basic nitrogen centers with arylboronic acids in water in the absence of added base are reported. The reactions proceed either partially or entirely under acidic conditions. After surveying twenty-two phosphorus ligands, high yields of products were obtained with aryl chlorides only when a bulky ligand, 2-(di-tert-butyl-phosphino)-1-phenyl-1H-pyrrole (cataCXiumPtB) was used. In contrast, aryl bromides produced high yields of products in the absence of both added base and added ligand. In order to explore the Suzuki coupling process entirely under acidic conditions, a series of reactions were conducted in buffered acidic media using several model substrates. 4-Chlorobenzylamine, in the presence of cataCXiumPtB, produced high yields of product at buffered pH 6.0; the yields dropped off precipitously at buffered pH 5.0 and lower. The fall-off in yield was attributed to the decomposition of the Pd-ligand complex due to the protonation of the ligand in the more acidic aqueous media. In contrast, in the absence of an added ligand, 4-amino-2-chloropyridine produced quantitative yields at buffered pH 3.5 and 4.5 while 4-amino-2-bromopyridine produced quantitative yields in a series of buffered media ranging from pH 4.5 to 1.5. These substrates are only partially protonated in acidic media and can behave as active Pd ligands in the Suzuki catalytic cycle.

Synthesis and evaluation of sulfonamide derivatives as potent Human Uric Acid Transporter 1 (hURAT1) inhibitors

This letter presents synthesis and structure-activity relationship study of sulfonamide derivatives as inhibitors of Human Uric Acid Transporter 1 (hURAT1). Among all tested sulfonamide derivatives, compounds 9b, 16i and 19b exhibited excellent inhibition activity with IC50 value of 10, 2, and 83?nM, respectively. In addition, compounds 9b and 19b demonstrated moderate PK profile in rats.