125867-31-4 Usage
General Description
4-[(2,2-DIMETHYLPROPANOYL)AMINO]NICOTINIC ACID, also known as Laropiprant, is a pharmaceutical compound used in combination with niacin to reduce the incidence of flushing in patients treated with niacin for primary hypercholesterolemia or mixed dyslipidemia. It is a nicotinic acid receptor antagonist that works to inhibit prostaglandin D2 (PGD2) and reduce the vasodilatory effects of niacin, thereby reducing flushing. Laropiprant is a potent and selective inhibitor of the prostaglandin D2 receptor subtype 1 (DP1) and is primarily metabolized by the liver. It is available in oral tablet form and is typically used under the supervision of a healthcare professional.
Check Digit Verification of cas no
The CAS Registry Mumber 125867-31-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,5,8,6 and 7 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 125867-31:
(8*1)+(7*2)+(6*5)+(5*8)+(4*6)+(3*7)+(2*3)+(1*1)=144
144 % 10 = 4
So 125867-31-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H14N2O3/c1-11(2,3)10(16)13-8-4-5-12-6-7(8)9(14)15/h4-6H,1-3H3,(H,14,15)(H,12,13,16)
125867-31-4Relevant articles and documents
Synthesis of ortho-substituted aminopyridines. Metalation of pivaloylamino derivatives
Estel,Linard,Marsais,Godard,Queguiner
, p. 105 - 112 (2007/10/02)
The three isomeric pivaloylaminopyridines were lithiated in more than 80% yields. Aminopyridine derivatives were treated by 2.5-3 equivalents of the complex BuLi-TMEDA at -10° in diethyl ether. Reaction of the lithiated species with various electrophiles afforded a number of ortho-substituted pivaloylaminopyridines in good yields. Secondary pyridine alcohols were oxidized to the corresponding aminopyridyl ketones. Pyridopyrimidines, benzonaphthyridines as well as an analogue of the natural antitumor alkaloid ellipticine has been synthesized showing the versatility of the method.
Xi:Irritant;
