125867-31-4 Usage
Uses
Used in Pharmaceutical Industry:
4-[(2,2-DIMETHYLPROPANOYL)AMINO]NICOTINIC ACID is used as a pharmaceutical compound for the treatment of primary hypercholesterolemia or mixed dyslipidemia. It serves as an adjunct to niacin therapy, specifically to reduce the incidence of flushing, a common side effect of niacin treatment. By inhibiting the prostaglandin D2 receptor subtype 1 (DP1), Laropiprant effectively diminishes the vasodilatory effects of niacin, thus improving patient comfort and compliance during treatment.
Additionally, as a nicotinic acid receptor antagonist, 4-[(2,2-DIMETHYLPROPANOYL)AMINO]NICOTINIC ACID may have potential applications in other areas of medicine where modulation of prostaglandin D2 signaling is beneficial. However, further research and clinical trials would be necessary to explore and validate these potential uses.
Check Digit Verification of cas no
The CAS Registry Mumber 125867-31-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,5,8,6 and 7 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 125867-31:
(8*1)+(7*2)+(6*5)+(5*8)+(4*6)+(3*7)+(2*3)+(1*1)=144
144 % 10 = 4
So 125867-31-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H14N2O3/c1-11(2,3)10(16)13-8-4-5-12-6-7(8)9(14)15/h4-6H,1-3H3,(H,14,15)(H,12,13,16)
125867-31-4Relevant academic research and scientific papers
Synthesis of ortho-substituted aminopyridines. Metalation of pivaloylamino derivatives
Estel,Linard,Marsais,Godard,Queguiner
, p. 105 - 112 (2007/10/02)
The three isomeric pivaloylaminopyridines were lithiated in more than 80% yields. Aminopyridine derivatives were treated by 2.5-3 equivalents of the complex BuLi-TMEDA at -10° in diethyl ether. Reaction of the lithiated species with various electrophiles afforded a number of ortho-substituted pivaloylaminopyridines in good yields. Secondary pyridine alcohols were oxidized to the corresponding aminopyridyl ketones. Pyridopyrimidines, benzonaphthyridines as well as an analogue of the natural antitumor alkaloid ellipticine has been synthesized showing the versatility of the method.
Xi:Irritant;
