125867-35-8Relevant academic research and scientific papers
Synthesis and evaluation of novel 3,4,6-substituted 2-quinolones as FMS kinase inhibitors
Wall, Mark J.,Chen, Jinsheng,Meegalla, Sanath,Ballentine, Shelley K.,Wilson, Kenneth J.,DesJarlais, Renee L.,Schubert, Carsten,Chaikin, Margery A.,Crysler, Carl,Petrounia, Ioanna P.,Donatelli, Robert R.,Yurkow, Edward J.,Boczon, Lisa,Mazzulla, Marie,Player, Mark R.,Patch, Raymond J.,Manthey, Carl L.,Molloy, Christopher,Tomczuk, Bruce,Illig, Carl R.
, p. 2097 - 2102 (2008/12/21)
A series of 3,4,6-substituted 2-quinolones has been synthesized and evaluated as inhibitors of the kinase domain of macrophage colony-stimulating factor-1 receptor (FMS). The fully optimized compound, 4-(4-ethyl-phenyl)-3-(2-methyl-3H-imidazol-4-yl)-2-qui
Synthesis of aza analogues of the anticancer agent batracylin
Martínez-Viturro, Carlos M.,Domínguez, Domingo
, p. 4707 - 4710 (2008/03/13)
Three series of pyrido-fused pyrimido[2,1-a]isoindol-7-ones were prepared from readily available (aminopyridinyl)(aryl)methanones by reduction followed by a Mitsunobu reaction with phthalimide and acid-catalysed cyclodehydration. This approach provides a wide variety of aza analogues of the antitumour agent batracylin.
Synthesis of ortho-substituted aminopyridines. Metalation of pivaloylamino derivatives
Estel,Linard,Marsais,Godard,Queguiner
, p. 105 - 112 (2007/10/02)
The three isomeric pivaloylaminopyridines were lithiated in more than 80% yields. Aminopyridine derivatives were treated by 2.5-3 equivalents of the complex BuLi-TMEDA at -10° in diethyl ether. Reaction of the lithiated species with various electrophiles afforded a number of ortho-substituted pivaloylaminopyridines in good yields. Secondary pyridine alcohols were oxidized to the corresponding aminopyridyl ketones. Pyridopyrimidines, benzonaphthyridines as well as an analogue of the natural antitumor alkaloid ellipticine has been synthesized showing the versatility of the method.
