125872-85-7Relevant academic research and scientific papers
Dialkylzinc-mediated allylic polyfluoroarylation reaction
Kurauchi, Daisuke,Hirano, Keiichi,Kato, Hisano,Saito, Tatsuo,Miyamoto, Kazunori,Uchiyama, Masanobu
, p. 5849 - 5857 (2015/08/03)
Abstract We present an allylic polyfluoroarylation reaction with broad substrate scope and excellent functional group tolerance, using organozinc reagents under mild conditions. A catalytic amount of triphenylphosphine oxide efficiently promotes iodine-zinc exchange reaction between polyfluoroaryl iodide and dimethylzinc, and the resulting phosphine oxide-activated polyfluoroarylzinc undergoes substitution reaction with allylic halides to afford the corresponding polyfluoroarylated products.
Catalytic enantioselective dibromination of allylic alcohols
Hu, Dennis X.,Shibuya, Grant M.,Burns, Noah Z.
, p. 12960 - 12963 (2013/09/24)
A new dibromination reaction involving the combination of dibromomalonate as the bromonium source and a titanium bromide species as the bromide source has been developed. Enantioselective catalysis has been achieved through apparent ligand acceleration by a tartaric acid-derived diol.
