125872-98-2

Upstream product

• 3011-34-5 4-hydroxy-3-nitrobenzaldehyde 
• 106-95-6 allyl bromide 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 1360446-28-1 C₂₄H₂₉NO₁₃ 
• 1360446-29-2 C₃₁H₃₂N₂O₁₇ 
• 1360446-11-2 C₄₅H₅₁N₅O₁₇ 
• 1360446-14-5 C₃₇H₄₃N₅O₁₃ 
• 914769-85-0 C₁₀H₉NO₄ 
• 1360446-25-8 C₁₀H₁₁NO₄ 
• 1360446-27-0 C₂₄H₂₇NO₁₃ 
• 339587-96-1 1-allyloxy-4-dimethoxymethyl-2-nitro-benzene 
• 339588-02-2 Chloro-acetic acid (2R,3S,4R,5R,6S)-4-benzyloxy-2-(4-tert-butoxycarbonylmethoxy-3-nitro-benzyloxymethyl)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-6-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yl ester 
• 339587-99-4 2-[(2S,3R,4R,5S,6R)-6-(4-Allyloxy-3-nitro-benzyloxymethyl)-4-benzyloxy-5-hydroxy-2-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yl]-isoindole-1,3-dione 
• 339587-98-3 2-[(2R,4aR,6S,7R,8R,8aS)-2-(4-Allyloxy-3-nitro-phenyl)-8-benzyloxy-6-(4-methoxy-phenoxy)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-isoindole-1,3-dione 
• 339588-00-0 2-[(2S,3R,4R,5S,6R)-4-Benzyloxy-5-hydroxy-6-(4-hydroxy-3-nitro-benzyloxymethyl)-2-(4-methoxy-phenoxy)-tetrahydro-pyran-3-yl]-isoindole-1,3-dione 
• 339587-97-2 2-[(2R,4aR,6S,7R,8R,8aS)-2-(4-Allyloxy-3-nitro-phenyl)-8-hydroxy-6-(4-methoxy-phenoxy)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-isoindole-1,3-dione 
• 339588-01-1 {4-[(2R,3S,4R,5R,6S)-4-Benzyloxy-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-6-(4-methoxy-phenoxy)-tetrahydro-pyran-2-ylmethoxymethyl]-2-nitro-phenoxy}-acetic acid tert-butyl ester 

Relevant academic research and scientific papers

Metallated synthesis of intertwined, functionalized strands as precursors to molecularly woven materials

Herein we propose a novel approach toward yet to be realized molecularly woven materials (MWMs), based on metallated precursors containing intertwined strands with functional ends. Two different potential precursors, based on terminal alkene-functionalized bis-Schiff base ligands (with either 1,2-diaminophenylene or 1,2-diaminoethylene cores) coordinated around a Cu(i) ion, have been tested. During this work, four novel organic ligands were prepared, along with the Cu(i) or Ag(i) complexes of three of them, and were characterized by X-ray diffraction and/or NMR spectroscopy. Chemical reactivity and structural studies (by single-crystal X-ray crystallography) of these novel compounds led to the assessment of their viability as precursors for MWMs. The essential requirement that terminal functionalities on the two intertwined ligand strands of the precursor must be far enough from each other so that only inter- and no intra-molecular reactivity is possible, is only met by the precursor with a 1,2-diaminophenylene core. This precursor, however, is less stable than the analogous one with a 1,2-diaminoethylene core, as it easily undergoes intramolecular cyclization/aromatization to yield a stable benzimidazole moiety, resulting in breakdown of the strands. The benzimidazole-containing compound offers an interesting example of chiral crystallization (helical arrangement about a four-fold axis) induced by hydrogen bonding of an otherwise achiral molecule. The results of this study outline the challenges involved in the preparation of a MWM using our approach, and will aid in identifying more robust ligand systems that meet the requirements of a MWM precursor set forth here.

Second generation specific-enzyme-activated rotaxane propeptides

A [2]rotaxane, in which the peptidic axle is protected from degradation by the macrocyclic sheath and terminated with a novel glycosidase-cleavable stopper, is rendered water-soluble by derivatisation with tetra(ethylene glycol) (TetEG) or glucosylated te

ORGANIC COMPOUNDS

Novel substituted piperidines of the general formulae (I) and (II) with the substituent definitions as explained in detail in the description are described. The compounds are suitable in particular as renin inhibitors and are highly potent.

Divergent synthesis of sialylated glycan chains: Combined use of polymer support, resin capture-release, and chemoenzymatic strategies

(Chemical Equation Presented) Carbo loading! The synthesis of α(2,3)- or α(2,6)-sialylated biantennary glycans is possible with a new approach. The common precursor 1 was synthesized with a soluble polymer support strategy (a) in combination with a resin capture-release protocol. Hexasaccharide 1 can then be diverged to various polysaccharides by enzymatic glycosylation (b). Bn = benzyl, TBS = tert-butyldimethylsilyl.

Carbapenem antibiotic compounds

The present invention provides a compound of the formula: STR1 or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: A is a group of the formula (IA) or (IB): STR2 R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4 alkyl; R3 and R4 are the same or different and are a variety of substituents X is alkanediyl containing 1-6 carbon atoms optionally interrupted by O, S(O)x (wherein x is zero, one or two), --CONR5 -- or --NR5 -- or wherein R5 is hydrogen or C1-4 alkyl; or X is alkenediyl containing 1-6 carbon atoms optionally interrupted by O, S(O)x or --NR5 --.