1258730-18-5Relevant academic research and scientific papers
Organocatalytic Asymmetric Decarboxylative Amination of β-Keto Acids: Access to Optically Active α-Amino Ketones and 1,2-Amino Alcohols
Wei, Yi,Zhang, Heng-Xia,Zeng, Jun-Liang,Nie, Jing,Ma, Jun-An
, p. 2162 - 2165 (2017)
An organocatalytic asymmetric decarboxylative amination reaction of β-keto acids is described. Under mild reaction conditions, a series of chiral α-amino ketones were obtained in good to high yields (up to 99%) and enantioselectivities (up to 95% ee). A chiral 1,2-amino alcohol was synthesized from the corresponding decarboxylative amination product in several steps without loss of enantioselectivity.
Chiral calcium organophosphate-catalyzed enantioselective electrophilic amination of enamides
Drouet, Fleur,Lalli, Claudia,Liu, Hua,Masson, Geraldine,Zhu, Jieping
supporting information; experimental part, p. 94 - 97 (2011/03/22)
Highly enantioselective direct amination of enamides catalyzed by chiral nonracemic calcium bis(phosphate) complex 3g afforded optically active 1,2-hydrazinoimines 4. Following a subsequent in situ hydrolysis or reduction, 2-hydrazinoketones 5 or syn-1,2-
